PXD033995 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mice bone marrow-derived dendritic cells (BMDC) infected by Listeria: cell lysate proteome and PTMs |
Description | In this study, we aimed to determine the role of EVs derived from Lm-infected DCs in the innate response, and the potential role of HDAC6 in DEV loading under these conditions. Ourresults show that Lm infection induced an elevated production of DEVs. Lm infection also altered protein sorting. Interestingly, HDAC6 deletion altered DEV protein sorting, although it did not affect acetylation of DEV-loaded proteins. However, protein ubiquitination was severely altered. Here, we show that the protein content of dendritic cells (DCs) and their secreted EVs (DEVs) vary dramatically during Lm infection. The proteomic profiles of DC and DEV differ depending on whether HDAC6 is expressed or not. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:56:37.787.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Inmaculada Jorge |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | ubiquitinylated lysine; acetylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-19 03:32:15 | ID requested | |
1 | 2022-08-30 05:00:25 | announced | |
⏵ 2 | 2023-11-14 08:56:38 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: multiplexed quantitative proteomics, ubiquitinilation,Mouse, acetylation, HDAC6-KO, BMDendritic cells |
Contact List
Jesús María Vázquez Cobos |
contact affiliation | Centro Nacional de investigaciones Cardiovasculares, CNIC (Madrid, Spain) |
contact email | jvazquez@gmail.com |
lab head | |
Inmaculada Jorge |
contact affiliation | Vascular Biology and Inflammation |
contact email | ijorge@cnic.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD033995 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033995
- Label: PRIDE project
- Name: Mice bone marrow-derived dendritic cells (BMDC) infected by Listeria: cell lysate proteome and PTMs