PXD033965

PXD033965 is an original dataset announced via ProteomeXchange.

Title	Are Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.
Description	It is unclear to what extent Tau molecular pathology in murine models reflect human Tauopathies. Nevertheless, mouse models that overexpress human mutant Tau (P301S and P301L) are widely used in studies of Tauopathies and Alzheimer’s Disease (AD). In this study, we perform an in-depth temporally and spatially resolved mass spectrometry-based proteomic analysis of P301S (hTau.P301S) and P301L (rTg(tauP301L)4510) mice as well as human patients with AD or frontotemporal dementia due to the P301L mutation, to identify differences and similarities between human AD, animal models and human P301L patients. Both mouse models and human P301L patients show progressive Tau accumulation driven by Tau phosphorylation during disease progression as also observed in early human AD. However, Tau ubiquitination and acetylation, important in human AD, are less or not represented in the mouse models or in P301L patients. Our analyses provide guidance regarding designing mechanistic studies and testing of Tau directed therapeutics.
HostingRepository	PRIDE
AnnounceDate	2023-02-04
AnnouncementXML	Submission_2023-02-03_21:41:34.427.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	KathrinWenger
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monomethylated residue; S-carboxamidoethyl-L-cysteine; ubiquitination signature dipeptidyl lysine; phosphorylated residue; acetylated residue; L-citrulline
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-18 05:10:02	ID requested
⏵ 1	2023-02-03 21:41:34	announced

Dataset with its publication pending

submitter keyword: Are Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.

JudithSteen
contact affiliation	Neurobiology, Boston Children`s Hospital
contact email	Judith.Steen@childrens.harvard.edu
lab head
KathrinWenger
contact affiliation	Boston childrens hospital
contact email	Kathrin.wenger@childrens.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD033965

PRIDE project URI

• PRIDE
  1. PXD033965
     1. Label: PRIDE project
     2. Name: Are Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.