Updated project metadata. NQO2/QR2 is related to NQO1, a known quionine reductase that functions in detoxicification for cells. NQO2, however, uses a distinct co-substate with uncertain availability in cells and as a result the functions of NQO2 are poorly understood. Here, to gain insight into potential pathways regulated by NQO2, we performed label-free proteomics on isogenic control and NQO2 knockout HCT116 colon cancer cells.