PXD033944

PXD033944 is an original dataset announced via ProteomeXchange.

Title	Quinone reductase 2-dependent HCT116 proteome
Description	NQO2/QR2 is related to NQO1, a known quionine reductase that functions in detoxicification for cells. NQO2, however, uses a distinct co-substate with uncertain availability in cells and as a result the functions of NQO2 are poorly understood. Here, to gain insight into potential pathways regulated by NQO2, we performed label-free proteomics on isogenic control and NQO2 knockout HCT116 colon cancer cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:38.663.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthew Maitland
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-17 08:29:49	ID requested
1	2023-08-15 08:10:22	announced
⏵ 2	2023-11-14 09:04:39	announced	2023-11-14: Updated project metadata.

Gould NL, Scherer GR, Carvalho S, Shurrush K, Kayyal H, Edry E, Elkobi A, David O, Foqara M, Thakar D, Pavesi T, Sharma V, Walker M, Maitland M, Dym O, Albeck S, Peleg Y, Germain N, Babaev I, Sharir H, Lalzar M, Shklyar B, Hazut N, Khamaisy M, L, é, vesque M, Lajoie G, Avoli M, Amitai G, Lefker B, Subramanyam C, Shilton B, Barr H, Rosenblum K, Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice. J Clin Invest, 133(19):(2023) [pubmed]

submitter keyword: NQ02,HCT116, QR2

Brian Shilton
contact affiliation	Department of Biochemisty, The University of Western Ontario, London,Canada
contact email	bshilton@uwo.ca
lab head
Matthew Maitland
contact affiliation	University of Western Ontario
contact email	mmaitla2@uwo.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD033944

PRIDE project URI

• PRIDE
  1. PXD033944
     1. Label: PRIDE project
     2. Name: Quinone reductase 2-dependent HCT116 proteome