PXD033922

PXD033922 is an original dataset announced via ProteomeXchange.

Title	Protein interaction partners of long non-coding RNA NUDT6 in human aortic smooth muscle cells
Description	The long non-coding RNA NUDT6 was found to be deregulated in abdominal aortic aneurysm (AAA) with higher expression in diseased human tissue specimens versus control aortic tissue. Apart from the already well-studied DNA: RNA interaction as a natural antisense transcript to Fibroblast Growth Factor 2 (FGF2), we were interested in identifying protein interaction partners to unravel further involvement in the pathogenesis and progression of abdominal aortic aneurysm. Therefore, we performed a RNA pulldown experiment using biotinylated NUDT6 and control RNA in human aortic smooth muscle cell lysate to identify further interaction partners.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_06:22:23.651.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-16 08:25:26	ID requested
⏵ 1	2024-01-26 06:22:24	announced

10.1016/j.ymthe.2023.04.020;

Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, B, ä, cklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L, Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression. Mol Ther, 31(6):1775-1790(2023) [pubmed]

submitter keyword: abdominal aortic aneurysm, vascular disease, long non-coding RNAs,LC-MSMS, RNA/Protein Interaction

Lars Mägdefessel
contact affiliation	Klinikum rechts der Isar der TU München, Munich, Germany
contact email	lars.maegdefessel@tum.de
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD033922

PRIDE project URI

• PRIDE
  1. PXD033922
     1. Label: PRIDE project
     2. Name: Protein interaction partners of long non-coding RNA NUDT6 in human aortic smooth muscle cells