PXD033894

PXD033894 is an original dataset announced via ProteomeXchange.

Title	Murine and human bile proteome analysis
Description	The gut microbiota is known to influence host metabolism, but its impact on lipid uptake from the nutrition and underlying mechanisms remain mysterious. Combining lipidomics and proteomics we discovered a microbiome-related phospholipase A1 (PLA1) activity in bile.
HostingRepository	PRIDE
AnnounceDate	2026-07-30
AnnouncementXML	Submission_2026-07-30_00:05:16.713.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Piero Giansanti
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-13 07:01:01	ID requested
⏵ 1	2026-07-30 00:05:17	announced

10.1038/s41564-026-02434-z;

Brunner S, Plagge J, Zimmermann-Kogadeeva M, H, ö, ring M, Liebisch G, Basic M, Bolsega S, Janssen KP, Slack E, von Gamm S, Viehof-Beckmann A, Clavel T, Zimmermann M, Heeren J, Giansanti P, Weiss AS, Hermeling S, Dupont A, Ullrich AL, Jokisch F, Seeliger C, Bleich A, Hidrobo M, Stecher B, Coleman OI, Moresi C, Greter G, Arnoldini M, Scheiber J, Matysik S, Klingenspor M, K, ü, ster B, Haller D, Burkhardt R, Kuipers F, Ecker J, Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice. Nat Microbiol, 11(8):2349-2364(2026) [pubmed]

submitter keyword: proteomics, PLA activity, CEL, phospholipase A1,Bile

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany
contact email	kuster@tum.de
lab head
Piero Giansanti
contact affiliation	Technical University of Munich
contact email	piero.giansanti@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD033894

PRIDE project URI

• PRIDE
  1. PXD033894
     1. Label: PRIDE project
     2. Name: Murine and human bile proteome analysis