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PXD033876

PXD033876 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUnveiling human proteome signatures of heart failure with preserved ejection
DescriptionHeart Failure with preserved ejection fraction (HFpEF) is a major health challenge affecting millions of people worldwide. Moreover, this disease presents multiple etiologies and associated comorbidities, leading to difficulties in diagnosis and limited therapeutic options. HFpEF underlying cellular pathophysiological mechanisms require further investigation. In this study, quantitative proteomic analysis by advanced mass spectrometry (SWATH-MS) was employed to investigate signaling pathways and mechanisms that correlate with HFpEF. Protein expression profiles were analyzed in HFpEF and non-HFpEF human left ventricular myocardium biopsy samples. Functional analysis revealed several proteins that correlated with HFpEF, including proteins associated with mitochondrial dysfunction, oxidative stress reaction, and inflammation. Additionally, proteomic profiles of HFpEF patients with diabetes mellitus indicate reduced mitochondrial oxidative phosphorylation and fatty acid oxidation capacity. Data obtained also reflects the known heterogeneity of HFpEF clinical variables. The proteomic characterization described in this work provides new insights and raises new questions related to HFpEF cellular pathophysiology, paving the way to additional studies focused on the development of novel therapies and diagnosis strategies for HFpEF patients.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:35:35.589.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaria Joao Sebastiao
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-12 10:16:14ID requested
12022-11-29 08:40:47announced
22023-11-14 07:35:40announced2023-11-14: Updated project metadata.
Publication List
Sebasti, ã, o MJ, Almeida HV, Serra M, Hamdani N, Saraiva F, Louren, ç, o AP, Barros AS, Vasques-N, ó, voa F, Leite-Moreira A, Alves PM, Falc, ã, o-Pires I, Gomes-Alves P, Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction. Biomedicines, 10(11):(2022) [pubmed]
Keyword List
submitter keyword: heart failure with preserved ejection fraction
human myocardium ventricular samples
untargeted proteomics
Contact List
Patrícia Gomes Alves
contact affiliation1. iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal. 2. ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. Da República, 2780-157 Oeiras, Portugal.
contact emailpalves@ibet.pt
lab head
Maria Joao Sebastiao
contact affiliationiBET - Instituto de Biologia Experimental e Tecnológica
contact emailmsebastiao@ibet.pt
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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