PXD033876 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Unveiling human proteome signatures of heart failure with preserved ejection |
Description | Heart Failure with preserved ejection fraction (HFpEF) is a major health challenge affecting millions of people worldwide. Moreover, this disease presents multiple etiologies and associated comorbidities, leading to difficulties in diagnosis and limited therapeutic options. HFpEF underlying cellular pathophysiological mechanisms require further investigation. In this study, quantitative proteomic analysis by advanced mass spectrometry (SWATH-MS) was employed to investigate signaling pathways and mechanisms that correlate with HFpEF. Protein expression profiles were analyzed in HFpEF and non-HFpEF human left ventricular myocardium biopsy samples. Functional analysis revealed several proteins that correlated with HFpEF, including proteins associated with mitochondrial dysfunction, oxidative stress reaction, and inflammation. Additionally, proteomic profiles of HFpEF patients with diabetes mellitus indicate reduced mitochondrial oxidative phosphorylation and fatty acid oxidation capacity. Data obtained also reflects the known heterogeneity of HFpEF clinical variables. The proteomic characterization described in this work provides new insights and raises new questions related to HFpEF cellular pathophysiology, paving the way to additional studies focused on the development of novel therapies and diagnosis strategies for HFpEF patients. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:35:35.589.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maria Joao Sebastiao |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-12 10:16:14 | ID requested | |
1 | 2022-11-29 08:40:47 | announced | |
⏵ 2 | 2023-11-14 07:35:40 | announced | 2023-11-14: Updated project metadata. |
Publication List
Sebasti, ã, o MJ, Almeida HV, Serra M, Hamdani N, Saraiva F, Louren, ç, o AP, Barros AS, Vasques-N, ó, voa F, Leite-Moreira A, Alves PM, Falc, ã, o-Pires I, Gomes-Alves P, Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction. Biomedicines, 10(11):(2022) [pubmed] |
Keyword List
submitter keyword: heart failure with preserved ejection fraction |
human myocardium ventricular samples |
untargeted proteomics |
Contact List
Patrícia Gomes Alves |
contact affiliation | 1. iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal. 2. ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. Da República, 2780-157 Oeiras, Portugal. |
contact email | palves@ibet.pt |
lab head | |
Maria Joao Sebastiao |
contact affiliation | iBET - Instituto de Biologia Experimental e Tecnológica |
contact email | msebastiao@ibet.pt |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD033876 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033876
- Label: PRIDE project
- Name: Unveiling human proteome signatures of heart failure with preserved ejection