PXD033804

PXD033804 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Crosslinking mass spectrometry of the p300 catalytic core complexed with the nucleosome
Description	p300 is a histone acetyltransferase that associates with crucial biological processes. p300 acetylates all four histones in the nucleosome, a basic unit of chromatin, and alters chromatin structure and dynamics. In this study, we performed structural and biochemical analysis to understand the nucleosome binding by p300. Crosslinking mass spectrometry suggests that the p300 catalytic core binds to nucleosomes in multiple binding forms to acetylate different histone tails.
HostingRepository	jPOST
AnnounceDate	2022-06-29
AnnouncementXML	Submission_2022-09-18_03:50:54.311.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lumi Negishi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; unknown modification
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-11 04:19:46	ID requested
1	2022-06-29 00:59:09	announced
⏵ 2	2022-09-18 03:50:55	announced	2022-09-18: Updated FTP location.

Publication List

Hatazawa S, Liu J, Takizawa Y, Zandian M, Negishi L, Kutateladze TG, Kurumizaka H, Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. iScience, 25(7):104563(2022) [pubmed]

Hatazawa S, Liu J, Takizawa Y, Zandian M, Negishi L, Kutateladze TG, Kurumizaka H, Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. iScience, 25(7):104563(2022) [pubmed]

Keyword List

submitter keyword: p300, nucleosome, histone acetylation

submitter keyword: p300, nucleosome, histone acetylation

Contact List

Hitoshi Kurumizaka
lab head
Lumi Negishi
contact affiliation	The University of Tokyo
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001584/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001584/