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PXD033778

PXD033778 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal proteomic profiling of multiple organs of cat (Felis catus) and proteome-transcriptome correlation during acute Toxoplasma gondii infection
DescriptionUnderstanding altered expression of proteins and transcripts associated with Toxoplasma gondii infection in cats may improve our understanding of how this parasite manipulates the molecular microenvironment of the definitive host. We performed proteomics analysis of six organs (brain, heart, spleen, liver, lung and small intestine) in cats acutely infected with T. gondii. A total of 32,657 proteins were identified among the six examined organs, including 2,556 differentially expressed proteins (DEPs), of which 1,325 DEPs were up-regulated and 1,231 DEPs were down-regulated. The brain, liver, lung, spleen, heart and small intestine exhibited 125 DEPs, 463 DEPs, 255 DEPs, 283 DEPs, 855 DEPs and 675 DEPs, respectively. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed on all proteins and DEPs in all organs, showed that many proteins were enriched in binding, cell part, cell growth and death, signal transduction, translation, sorting and degradation and immune system. Correlation between proteins and transcripts with differential expression patterns were detected in the heart (n = 9), liver (n = 19), lung (n = 9), small intestine (n = 17), and spleen (n = 3). These DEPs were mainly involved in immune response, tryptophan catabolism, and extracellular matrix remodeling. Future investigations are needed to identify the pathophysiological mechanisms underlying the reported associations between the identified proteins and transcripts and T. gondii infection.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:39:35.392.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterQinli Liang
SpeciesList scientific name: Felis catus (Cat) (Felis silvestris catus); NCBI TaxID: 9685;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-09 05:33:13ID requested
12022-10-14 23:37:11announced
22023-11-14 07:39:41announced2023-11-14: Updated project metadata.
Publication List
Nie LB, Cong W, He JJ, Zheng WB, Zhu XQ, Global proteomic profiling of multiple organs of cats (Felis catus) and proteome-transcriptome correlation during acute Toxoplasma gondii infection. Infect Dis Poverty, 11(1):96(2022) [pubmed]
Keyword List
submitter keyword: Toxoplasma gondii, toxoplasmosis, cat, correlation, proteomic profiling
Contact List
xing-quan zhu
contact affiliationCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province 030801, People’s Republic China.
contact emailxingquanzhu1@hotmail.com
lab head
Qinli Liang
contact affiliationState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
contact emailliangqinli701@163.com
dataset submitter
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Dataset FTP location
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