PXD033714

PXD033714 is an original dataset announced via ProteomeXchange.

Title	Senescent cells display an altered immunopeptidome and promote CD8-dependent antitumor immunity
Description	Cellular senescence is a stress response known to activate innate immunity. However, how senescent cells interact with the adaptive immune system remains largely unexplored. Here, we show that senescent cells display an enhanced MHC class I antigen processing and presentation. Furthermore, senescent cells present an altered immunopeptidome including unique non-mutated antigens that can be recognized by specific CD8 T cells. Immunization of mice with senescent cancer cells triggers strong protective CD8-dependent antitumor responses, superior to immunogenic cell death. Similarly, induction of senescence in human primary cancer cells hyperactivates their cognate reactive CD8 T cell. Our study indicates that immunization with senescent cells provides a sustained source of antigens that strongly activate anti-tumor CD8 T cells.
HostingRepository	PRIDE
AnnounceDate	2022-10-18
AnnouncementXML	Submission_2022-10-18_10:27:14.662.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	EduardoZarzuela
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-05 01:24:47	ID requested
⏵ 1	2022-10-18 10:27:15	announced

Dataset with its publication pending

submitter keyword: Senescence, Plasma membrane

Javier MuñozPeralta
contact affiliation	CNIO
contact email	javier.munozperalta@osakidetza.eus
lab head
EduardoZarzuela
contact affiliation	Centro Nacional de Investigaciones Oncológicas
contact email	eduzarfer@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD033714
     1. Label: PRIDE project
     2. Name: Senescent cells display an altered immunopeptidome and promote CD8-dependent antitumor immunity