PXD033684 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model |
Description | Supplementation of the mother's diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100-days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified comparing both conditions, eight of them downregulated and three upregulated in the HTX-treated group. Downregulated proteins were mainly involved in protein synthesis and RNA metabolism, and may explain the differences in neuron differentiation in the HTX-treated group. Upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-12 |
AnnouncementXML | Submission_2022-08-11_23:39:25.308.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Montserrat Carrascal |
SpeciesList | scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-05 00:51:37 | ID requested | |
⏵ 1 | 2022-08-11 23:39:26 | announced | |
Publication List
Yeste N, P, é, rez-Valle J, V, á, zquez-G, ó, mez M, Garc, í, a-Contreras C, Gonz, á, lez-Bulnes A, Bassols A, Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model. Antioxidants (Basel), 11(6):(2022) [pubmed] |
Keyword List
submitter keyword: Hydroxytyrosol |
hippocampus |
intrauterine growth restriction |
brain |
pig |
proteome |
TMT labelling |
Contact List
Anna Bassols |
contact affiliation | Departament de Bioquímica i Biologia Molecular. Facultat de Veterinària. Universitat Autònoma de Barcelona. Cerdanyola del Vallès. 08193 Barcelona. Spain |
contact email | anna.bassols@uab.cat |
lab head | |
Montserrat Carrascal |
contact affiliation | IIBB-CSIC |
contact email | montserrat.carrascal.csic@uab.cat |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033684
- Label: PRIDE project
- Name: Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model