PXD033684

PXD033684 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
Description	Supplementation of the mother's diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100-days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified comparing both conditions, eight of them downregulated and three upregulated in the HTX-treated group. Downregulated proteins were mainly involved in protein synthesis and RNA metabolism, and may explain the differences in neuron differentiation in the HTX-treated group. Upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-11_23:39:25.308.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Montserrat Carrascal
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-05 00:51:37	ID requested
⏵ 1	2022-08-11 23:39:26	announced

Publication List

Yeste N, P, é, rez-Valle J, V, á, zquez-G, ó, mez M, Garc, í, a-Contreras C, Gonz, á, lez-Bulnes A, Bassols A, Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model. Antioxidants (Basel), 11(6):(2022) [pubmed]

Yeste N, P, é, rez-Valle J, V, á, zquez-G, ó, mez M, Garc, í, a-Contreras C, Gonz, á, lez-Bulnes A, Bassols A, Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model. Antioxidants (Basel), 11(6):(2022) [pubmed]

Keyword List

submitter keyword: Hydroxytyrosol
hippocampus
intrauterine growth restriction
brain
pig
proteome
TMT labelling

submitter keyword: Hydroxytyrosol

hippocampus

intrauterine growth restriction

brain

pig

proteome

TMT labelling

Contact List

Anna Bassols
contact affiliation	Departament de Bioquímica i Biologia Molecular. Facultat de Veterinària. Universitat Autònoma de Barcelona. Cerdanyola del Vallès. 08193 Barcelona. Spain
contact email	anna.bassols@uab.cat
lab head
Montserrat Carrascal
contact affiliation	IIBB-CSIC
contact email	montserrat.carrascal.csic@uab.cat
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD033684
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD033684

PRIDE project URI

Repository Record List

[ + ]