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PXD033683

PXD033683 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleShort-term blockade of pro-inflammatory alarmin S100A9 fa-vorably modulates left ventricle proteome and related signaling pathways involved in post – myocardial infarction recovery
DescriptionPrognosis after myocardial infarction (MI) varies greatly depending of the extent of damaged area and the management of biological processes during recovery. Reportedly, the inhibition of the pro-inflammatory S100A9 reduces myocardial damage after MI. We hypothesize that S100A9 blockade induces changes of major signaling pathways implicated in post-MI healing. The S100A9 blocker (ABR-23890) was given for 3 days after coronary ligation. At 3- and 7-days post-MI, ventricle samples were analyzed versus control and sham-operated mice. Blockade of S100A9 modulated the expressed proteins involved in five biological processes: leu-kocyte cell-cell adhesion, regulation of muscle cell apoptotic process, regulation of intrinsic apoptotic signaling pathway, sarcomere organization and cardiac muscle hypertrophy. The blocker induced regulation of 36 proteins interacting with or targeted by the cellular tumor antigen p53, prevented myocardial compensatory hypertrophy, and reduced cardiac markers of post-ischemic stress. The blockade effect was prominent at day 7 post-MI when the quantitative features of ventricle proteome were closer to controls.
HostingRepositoryPRIDE
AnnounceDate2022-05-19
AnnouncementXMLSubmission_2022-05-19_02:37:38.698.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFelicia Antohe
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-05 00:51:17ID requested
12022-05-19 02:37:39announced
Publication List
Boteanu RM, Suica VI, Uyy E, Ivan L, Cerveanu-Hogas A, Mares RG, Simionescu M, Schiopu A, Antohe F, Short-Term Blockade of Pro-Inflammatory Alarmin S100A9 Favorably Modulates Left Ventricle Proteome and Related Signaling Pathways Involved in Post-Myocardial Infarction Recovery. Int J Mol Sci, 23(9):(2022) [pubmed]
Keyword List
submitter keyword: S100A9, myocardial infarction, apoptosis, hypertrophy, cardiac repair
Contact List
Felicia Antohe
contact affiliationInstitute of Cellular Biology and Pathology
contact emailfelicia.antohe@icbp.ro
lab head
Felicia Antohe
contact affiliationInstitute of Cellular Biology and Pathology "N. Simionescu"
contact emailfelicia.antohe@icbp.ro
dataset submitter
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Dataset FTP location
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