PXD033646

PXD033646 is an original dataset announced via ProteomeXchange.

Title	Proteomic assessment of C57BL/6 hippocampi after non-selective pharmacological inhibition of all nitric oxide synthase activity
Description	Nitric oxide is the smallest gaseous signaling molecule responsible for maintaining homeostasis in a myriad of tissues and molecular pathways in neurological and cardiovascular pathologies. In recent years, there has been increasing interest in the potential interaction between arterial stiffness (AS), an independent cardiovascular risk factor, and neurodegenerative syndromes given increasingly epidemiological study reports. For this reason, we previously sought to investigate the mechanistic convergence between AS and neurodegeneration via the progressive non-selective inhibition of all nitric oxide synthase (NOS) isoforms with N(G)-nitro-L-arginine methyl ester (L-NAME) in C57BL/6 mice. Our results showed progressively increased arterial stiffness in vivo and impaired visuospatial learning and memory in L-NAME treated C57BL/6 mice. In this study, we sought to further investigate the progressive molecular signatures in hippocampal tissue via LC-MS/MS proteomic analysis
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:07:34.990.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Delphi Van Haver
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-04 14:46:39	ID requested
⏵ 1	2022-08-12 00:07:35	announced

Hendrickx JO, Adams C, Sieben A, Laukens K, Van Dam D, De Meyer GRY, Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy. Biomedicines, 10(8):(2022) [pubmed]

submitter keyword: Mouse, hippocampus, nitric oxide, LC-MSMS

Guido De Meyer
contact affiliation	Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
contact email	guido.demeyer@uantwerpen.be
lab head
Delphi Van Haver
contact affiliation	VIB Proteomics Core
contact email	delphi.vanhaver@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD033646

PRIDE project URI

• PRIDE
  1. PXD033646
     1. Label: PRIDE project
     2. Name: Proteomic assessment of C57BL/6 hippocampi after non-selective pharmacological inhibition of all nitric oxide synthase activity