PXD033603

PXD033603 is an original dataset announced via ProteomeXchange.

Title	The salivary proteome in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients: a labelled and label-free proteomics approach-TMTdata
Description	Decreased salivary flow rates and/or changes in protein composition reported after autologous hematopoietic stem cell transplantation (ASCT) reduces the protective function of saliva. This might be associated with the development of oral mucositis (OM), an inflammation of the oral mucosa as a result of chemotherapy before ASCT which affects patients? quality of life and risk factor for systemic infections. In this study, a TMT-labelled proteomics experiment, a label-free quantification (LFQ) proteomics experiment and a DIA-MS proteomics experiment were used to identify differences in the salivary proteome between patients with ulcerative OM (uOM; WHO score ? 2) and those without (nOM). For the TMT-labelled experiment, saliva samples of 5 uOM and 5 nOM were pooled at different time points: baseline, 1, 2, and 3 weeks after ASCT and 3 months after ASCT. A different salivary proteome was suggested by a distinct clustering of the OM pools at baseline, week 2 and week 3 after ASCT.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:04:25.946.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD033603
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	An Staes
SpeciesList	scientific name: human oral bacteria ensemble; NCBI TaxID: 150596; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-04 09:19:11	ID requested
1	2023-07-10 01:58:24	announced
⏵ 2	2023-11-14 07:04:26	announced	2023-11-14: Updated project metadata.

10.6019/PXD033603;

submitter keyword: LC-MS, TMT-labelled proteomics,TMT-MS, Label-free quantification, Saliva,Oral Mucositis, Autologous hematopoietic stem cell transplantation, Multiple Myeloma,DIA-MS

Nicole M.A. Blijlevens
contact affiliation	Radboud university medical center, Radboud Institute for Health Sciences, Department of Hematology The Netherlands
contact email	Nicole.Blijlevens@radboudumc.nl
lab head
An Staes
contact affiliation	Medical Protein Chemistry
contact email	an.staes@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD033603

PRIDE project URI

• PRIDE
  1. PXD033603
     1. Label: PRIDE project
     2. Name: The salivary proteome in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients: a labelled and label-free proteomics approach-TMTdata