PXD033599

PXD033599 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	NET proteome of neutrophils from people with long-standing type 1 diabetes and healthy control
Description	Type 1 diabetes (T1D) is a chronic T-cell-mediated autoimmune disease, leading to the destruction of the pancreatic insulin-producing beta cells. Little is known about the involvement of neutrophils that exert multifaceted functions like phagocytosis, degranulation, production of cytokines and the formation of neutrophil extracellular traps (NETosis), in the pathogenesis of T1D. Our aim was to gain insight into the proteome of neutrophils undergoing NETosis from patients with long-standing T1D compared to age- and sex-matched healthy controls under both resting and stimulated conditions (phorbol-myristate acetate, PMA, 100nM; ionomycin, 20µM; 3hours) by LC/MS-MS.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:56:07.537.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD033599
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Samal Bissenova
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-04 09:17:26	ID requested
1	2023-05-15 01:49:11	announced
⏵ 2	2023-11-14 08:56:07	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD033599;

10.6019/PXD033599;

Keyword List

submitter keyword: Human, LC-MSMS, NETosis, neutrophils, type 1 diabetes

submitter keyword: Human, LC-MSMS, NETosis, neutrophils, type 1 diabetes

Contact List

Chantal Mathieu
contact affiliation	Clinical and Experimental Endocrinology Department, KU Leuven, Leuven, Belgium
contact email	chantal.mathieu@uzleuven.be
lab head
Samal Bissenova
contact affiliation	KU Leuven
contact email	samal.bissenova@kuleuven.be
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD033599
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD033599

PRIDE project URI

Repository Record List

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