PXD033587

PXD033587 is an original dataset announced via ProteomeXchange.

Title	TET1 interactome by SILAC IP-MS in mouse ESCs
Description	TET1 maintains hypomethylation at bivalent promoters through its catalytic activity in embryonic stem cells (ESCs). However, whether and how TET1 exerts catalytic activity-independent functions in regulating bivalent genes is not well understood. Therefore, we mapped the TET1 interactome in mouse ESCs using a SILAC IP-MS proteomics approach.
HostingRepository	PRIDE
AnnounceDate	2022-06-10
AnnouncementXML	Submission_2022-06-09_17:51:16.285.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Huang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	6x(13)C labeled residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-04 09:14:37	ID requested
⏵ 1	2022-06-09 17:51:16	announced

Huang X, Bashkenova N, Hong Y, Lyu C, Guallar D, Hu Z, Malik V, Li D, Wang H, Shen X, Zhou H, Wang J, A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. Cell Rep, 39(10):110928(2022) [pubmed]

submitter keyword: TET1, SILAC, IP-MS, ESCs

Jianlong Wang
contact affiliation	Department of Medicine, Columbia University Irving Medical Center
contact email	jw3925@cumc.columbia.edu
lab head
Xin Huang
contact affiliation	Department of Medicine, Columbia University Irving Medical Center
contact email	xh2200@cumc.columbia.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD033587

PRIDE project URI

• PRIDE
  1. PXD033587
     1. Label: PRIDE project
     2. Name: TET1 interactome by SILAC IP-MS in mouse ESCs