PXD033582

PXD033582 is an original dataset announced via ProteomeXchange.

Title	Targeting parvalbumin promotes M2 macrophage polarization energy expenditure in diet-induced mouse obesity models
Description	Exercise benefits M2 macrophage polarization, energy homeostasis and protects against obesity partially through exercise-induced circulating factors. Here, by unbiased quantitative proteomics on serum samples from sedentary and exercised mice, we identify parvalbumin as a circulating factor suppressed by exercise. Parvalbumin functions as a non-competitive CSF1R antagonist to inhibit M2 macrophage activation and energy expenditure in adipose tissue. More importantly, serum concentrations of parvalbumin positively correlate with obesity in mouse and human, while treating mice with a recombinant parvalbumin blocker prevents its interaction with CSF1R and promotes M2 macrophage polarization and ameliorates diet-induced obesity. Thus, although further studies are required to assess the significance of parvalbumin in mediating the effects of exercise, our results implicate parvalbumin as a potential therapeutic strategy against obesity.
HostingRepository	PRIDE
AnnounceDate	2022-05-10
AnnouncementXML	Submission_2022-05-10_02:14:52.419.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shaojian Lin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-04 09:10:00	ID requested
⏵ 1	2022-05-10 02:14:52	announced

Dataset with its publication pending

submitter keyword: Mouse，serum，TMT，HPLC-MS/MS

Bing Luan
contact affiliation	Department of Endocrinology, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, 1239 Siping Road, Shanghai 200092, China.
contact email	bluan@tongji.edu.cn
lab head
Shaojian Lin
contact affiliation	Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
contact email	shaojianlin88@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD033582

PRIDE project URI

• PRIDE
  1. PXD033582
     1. Label: PRIDE project
     2. Name: Targeting parvalbumin promotes M2 macrophage polarization energy expenditure in diet-induced mouse obesity models