PXD033536
PXD033536 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The pivotal and universal role of BGLT3 lncRNA in fetal globin gene expression |
Description | A highly selective and non-genotoxic G9a inhibitor, RK-701 was discovered, which upregulated the mRNA level of γ-globin but not β-globin both in human erythroid cells and in mice. Using RK-701, we examined the induction of the fetal (γ-) globin protein in human erythroid cells; HUDEP-2 and human CD34+ bone marrow and peripheral blood cells. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:24:32.562.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD033536 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Masaya Usui |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-04-28 01:43:57 | ID requested | |
1 | 2023-03-10 16:59:58 | announced | |
⏵ 2 | 2023-11-14 08:24:34 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD033536; |
Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, Matsuoka S, Sonoda T, Niwa H, Sato S, Umehara T, Shirouzu M, Nishigaya Y, Sumiya T, Hashimoto N, Namie R, Usui M, Ohishi T, Ohba SI, Kawada M, Hayashi Y, Harada H, Yamaguchi T, Shinkai Y, Nakamura Y, Yoshida M, Ito A, A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun, 14(1):23(2023) [pubmed] |
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Epigenetic Chromatin (B/D-HPP), Human Proteome Project |
submitter keyword: hemoglobin subunit,Cultured cell, LC-MS/MS |
Contact List
Akihiro Ito | |
---|---|
contact affiliation | Tokyo University of Pharmacy and Life Sciences |
contact email | aito@toyaku.ac.jp |
lab head | |
Masaya Usui | |
contact affiliation | Support Unit for Bio-Material Analysis, Research Resources Division, RIKEN Center for Brain Science |
contact email | masaya.usui@riken.jp |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD033536 |
PRIDE project URI |
Repository Record List
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