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PXD033536

PXD033536 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe pivotal and universal role of BGLT3 lncRNA in fetal globin gene expression
DescriptionA highly selective and non-genotoxic G9a inhibitor, RK-701 was discovered, which upregulated the mRNA level of γ-globin but not β-globin both in human erythroid cells and in mice. Using RK-701, we examined the induction of the fetal (γ-) globin protein in human erythroid cells; HUDEP-2 and human CD34+ bone marrow and peripheral blood cells.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:24:32.562.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD033536
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMasaya Usui
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-28 01:43:57ID requested
12023-03-10 16:59:58announced
22023-11-14 08:24:34announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD033536;
Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, Matsuoka S, Sonoda T, Niwa H, Sato S, Umehara T, Shirouzu M, Nishigaya Y, Sumiya T, Hashimoto N, Namie R, Usui M, Ohishi T, Ohba SI, Kawada M, Hayashi Y, Harada H, Yamaguchi T, Shinkai Y, Nakamura Y, Yoshida M, Ito A, A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun, 14(1):23(2023) [pubmed]
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Epigenetic Chromatin (B/D-HPP), Human Proteome Project
submitter keyword: hemoglobin subunit,Cultured cell, LC-MS/MS
Contact List
Akihiro Ito
contact affiliationTokyo University of Pharmacy and Life Sciences
contact emailaito@toyaku.ac.jp
lab head
Masaya Usui
contact affiliationSupport Unit for Bio-Material Analysis, Research Resources Division, RIKEN Center for Brain Science
contact emailmasaya.usui@riken.jp
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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