PXD033469

PXD033469 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Role of circNFKB1 in cartilage degeneration of knee osteoarthritis and its mechanism
Description	Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules produced by reverse splicing of the precursor mRNAs of thousands of gene exons in eukaryotes. Some circRNAs play potentially important roles at the molecular level through different modes of action in physiological and pathological conditions. In recent years, it has been found that differentially expressed circRNAs are present in chondrocyte degeneration in OA and are able to modulate the inflammatory response in chondrocyte degeneration. However, the molecular mechanisms of how circRNAs regulate the inflammatory response during chondrogenic degeneration in OA have not been adequately studied. Are there other circRNAs involved in regulating the inflammatory response during knee OA chondrocyte degeneration and are there other molecular mechanisms by which circRNAs regulate chondrocyte degeneration? These scientific questions deserve relevant studies.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:31:01.932.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nie Xiaoyu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Dionex instrument model

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-27 03:47:03	ID requested
1	2022-10-14 20:35:27	announced
⏵ 2	2023-11-14 08:31:02	announced	2023-11-14: Updated project metadata.

Publication List

Tang S, Nie X, Ruan J, Cao Y, Kang J, Ding C, B signaling. Cell Death Dis, 13(8):695(2022) [pubmed]

Tang S, Nie X, Ruan J, Cao Y, Kang J, Ding C, B signaling. Cell Death Dis, 13(8):695(2022) [pubmed]

Keyword List

submitter keyword: Osteoarthritis
circRNA;

submitter keyword: Osteoarthritis

circRNA;

Contact List

Changhai Ding
contact affiliation	Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China
contact email	tangsan@mail2.sysu.edu.cn
lab head
Nie Xiaoyu
contact affiliation	Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China
contact email	1329368879@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD033469
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD033469

PRIDE project URI

Repository Record List

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