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PXD033293

PXD033293 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis neutrophils from COVID-19 patients
DescriptionTo go further insight into the involvement of neutrophils in COVID-19 clinical expression, we performed a proteomic analysis of this blood cell type in COVID-19 patients and two non-infected SARS-CoV-2 control groups composed of healthy subjects and ARDS patients hospitalized in intensive care unit (ICU) respectively. All patients were from Guadeloupe and represent a homogeneous population. We have performed a quantitative proteomic study of neutrophiles from French hot spot COVID region, Guadeloupe, confirming the activation of type I IFN pathway and in some target of IFN as TAP proteins, specifically in COVID patients, but not in hospitalized ARDS non-COVID patients and described modification of the NET proteome potentially associated with ARDS.
HostingRepositoryPRIDE
AnnounceDate2022-07-27
AnnouncementXMLSubmission_2022-07-27_06:38:50.248.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEmilie-Fleur GAUTIER
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-19 03:16:56ID requested
12022-07-27 06:38:50announced
Publication List
Romana M, Leduc M, Hermand P, Bruce J, Gautier EF, Martino F, Garnier Y, Baccini V, Le Van Kim C, Proteomic analysis of neutrophils from patients with COVID-19. Br J Haematol, 199(1):61-64(2022) [pubmed]
Keyword List
submitter keyword: Neutrophil, Labelfree, COVID-19, TIMS-TOF
Contact List
Emilie-Fleur Gautier
contact affiliationLaboratoire d’Excellence GR-Ex, Paris, France 3P5 Proteom’IC facility, Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014 PARIS, France
contact emailef.gautier.upd@gmail.com
lab head
Emilie-Fleur GAUTIER
contact affiliationPlateforme Proteomique 3P5, Université Paris Descartes, Inserm U1016, Institut Cochin, Cnrs UMR8104, France
contact emailef.gautier.upd@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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