PXD033248

PXD033248 is an original dataset announced via ProteomeXchange.

Title	Label free quantitative proteomic analysis on (-)-epicatechin (EC) and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV) treated Caco-2 and Hepa1c1c7 cells
Description	Epicatechin (EC) is a well-known dietary polyphenol and widely found in various foods, e.g., apple, cocoa, green tea, wine, etc. Its consumption has been associated with attenuation of some chronic diseases. After ingestion of EC, a large portion is passed into the large intestinal lumen where it is extensively degraded into various microbial metabolites. One of the major EC microbial metabolites is 5-(3’,4’-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV). The protein expression profiles of EC or 3,4-diHPV treated Caco-2 and Hepa1c1c7 cells were studied with the help of label-free quantitative proteomics. Compared to the parent compound EC, 3,4-diHPV was able to induce upregulations of more Nrf2-related proteins in both cell lines, and the number of significant differentially expressed proteins (DEPs) induced by 3,4-diHPV in Hepa1c1c7 cells was much higher than the respective EC treatment.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:46:19.641.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sjef Boeren
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-14 05:38:54	ID requested
⏵ 1	2022-08-12 00:46:20	announced

Liu C, Boeren S, Rietjens IMCM, -Valerolactone in Regulating Nrf2-Mediated Gene Expression. Front Nutr, 9():910785(2022) [pubmed]

submitter keyword: 5-(3’,4’-dihydroxyphenyl)-γ-valerolactone, (-)-epicatechin, Caco-2, Hepa1c1c7

Sjef Boeren
contact affiliation	Wageningen University
contact email	sjef.boeren@wur.nl
lab head
Sjef Boeren
contact affiliation	Biochemistry
contact email	sjef.boeren@wur.nl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD033248
     1. Label: PRIDE project
     2. Name: Label free quantitative proteomic analysis on (-)-epicatechin (EC) and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV) treated Caco-2 and Hepa1c1c7 cells