PXD033248 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Label free quantitative proteomic analysis on (-)-epicatechin (EC) and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV) treated Caco-2 and Hepa1c1c7 cells |
Description | Epicatechin (EC) is a well-known dietary polyphenol and widely found in various foods, e.g., apple, cocoa, green tea, wine, etc. Its consumption has been associated with attenuation of some chronic diseases. After ingestion of EC, a large portion is passed into the large intestinal lumen where it is extensively degraded into various microbial metabolites. One of the major EC microbial metabolites is 5-(3’,4’-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV). The protein expression profiles of EC or 3,4-diHPV treated Caco-2 and Hepa1c1c7 cells were studied with the help of label-free quantitative proteomics. Compared to the parent compound EC, 3,4-diHPV was able to induce upregulations of more Nrf2-related proteins in both cell lines, and the number of significant differentially expressed proteins (DEPs) induced by 3,4-diHPV in Hepa1c1c7 cells was much higher than the respective EC treatment. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-12 |
AnnouncementXML | Submission_2022-08-12_00:46:19.641.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sjef Boeren |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | S-carboxamidoethyl-L-cysteine; acetylated residue; monohydroxylated residue; deamidated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-14 05:38:54 | ID requested | |
⏵ 1 | 2022-08-12 00:46:20 | announced | |
Publication List
Liu C, Boeren S, Rietjens IMCM, -Valerolactone in Regulating Nrf2-Mediated Gene Expression. Front Nutr, 9():910785(2022) [pubmed] |
Keyword List
submitter keyword: 5-(3’,4’-dihydroxyphenyl)-γ-valerolactone, (-)-epicatechin, Caco-2, Hepa1c1c7 |
Contact List
Sjef Boeren |
contact affiliation | Wageningen University |
contact email | sjef.boeren@wur.nl |
lab head | |
Sjef Boeren |
contact affiliation | Biochemistry |
contact email | sjef.boeren@wur.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD033248
- Label: PRIDE project
- Name: Label free quantitative proteomic analysis on (-)-epicatechin (EC) and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV) treated Caco-2 and Hepa1c1c7 cells