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PXD033248

PXD033248 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLabel free quantitative proteomic analysis on (-)-epicatechin (EC) and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV) treated Caco-2 and Hepa1c1c7 cells
DescriptionEpicatechin (EC) is a well-known dietary polyphenol and widely found in various foods, e.g., apple, cocoa, green tea, wine, etc. Its consumption has been associated with attenuation of some chronic diseases. After ingestion of EC, a large portion is passed into the large intestinal lumen where it is extensively degraded into various microbial metabolites. One of the major EC microbial metabolites is 5-(3’,4’-dihydroxyphenyl)-γ-valerolactone (3,4-diHPV). The protein expression profiles of EC or 3,4-diHPV treated Caco-2 and Hepa1c1c7 cells were studied with the help of label-free quantitative proteomics. Compared to the parent compound EC, 3,4-diHPV was able to induce upregulations of more Nrf2-related proteins in both cell lines, and the number of significant differentially expressed proteins (DEPs) induced by 3,4-diHPV in Hepa1c1c7 cells was much higher than the respective EC treatment.
HostingRepositoryPRIDE
AnnounceDate2022-08-12
AnnouncementXMLSubmission_2022-08-12_00:46:19.641.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSjef Boeren
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidoethyl-L-cysteine; acetylated residue; monohydroxylated residue; deamidated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-14 05:38:54ID requested
12022-08-12 00:46:20announced
Publication List
Liu C, Boeren S, Rietjens IMCM, -Valerolactone in Regulating Nrf2-Mediated Gene Expression. Front Nutr, 9():910785(2022) [pubmed]
Keyword List
submitter keyword: 5-(3’,4’-dihydroxyphenyl)-γ-valerolactone, (-)-epicatechin, Caco-2, Hepa1c1c7
Contact List
Sjef Boeren
contact affiliationWageningen University
contact emailsjef.boeren@wur.nl
lab head
Sjef Boeren
contact affiliationBiochemistry
contact emailsjef.boeren@wur.nl
dataset submitter
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Dataset FTP location
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