PXD033242

PXD033242 is an original dataset announced via ProteomeXchange.

Title	Arginine-derived polyketides are ubiquitous signals shaping cross-kingdom microbial interactions
Description	Microbial consortia consist of a multitude of prokaryotic and eukaryotic microorganisms. Their interaction is critical for the functioning of ecosystems. Until now, there is limited knowledge about the communication signals determining the interaction between bacteria and fungi and how they influence microbial consortia. Here, we discovered that bacterial low molecular weight arginine-derived polyketides trigger the production of distinct natural products in fungi. These compounds are produced by actinomycetes found on all continents except Antarctica and are characterized by an arginine-derived positively charged group linked to a linear or cyclic polyene moiety. Producer bacteria can be readily isolated from soil as well as fungi that decode the signal and respond with the biosynthesis of natural products. Both arginine-derived polyketides and the compounds produced by fungi in response shape microbial interactions.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:00:49.483.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Krüger
SpeciesList	scientific name: Streptomyces iranensis; NCBI TaxID: 576784;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-14 05:29:35	ID requested
1	2023-06-16 02:49:04	announced
⏵ 2	2023-11-14 09:00:50	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: bacterial-fungal interaction,Streptomyces iranensis, polyketides, marginolactones, LC-MS/MS

Axel A. Brakhage
contact affiliation	Department for Molecular and Applied Microbiology, Leibniz-Institute for Natural Product Research and Infection Biology, Hans Knöll Institute Jena, Germany
contact email	axel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliation	Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact email	thomas.krueger@leibniz-hki.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD033242

PRIDE project URI

• PRIDE
  1. PXD033242
     1. Label: PRIDE project
     2. Name: Arginine-derived polyketides are ubiquitous signals shaping cross-kingdom microbial interactions