PXD033227

PXD033227 is an original dataset announced via ProteomeXchange.

Title	AKT/PACS2 participates in renal vascular hyperpermeability by regulating endothelial fatty acid oxidation in diabetic mice
Description	HUVECs were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in an Endothelial Cell Medium (Invitrogen, Carlsbad, CA, USA) containing 5% fetal bovine serum at 37°C in a 5% CO2 incubator. Cells were treated with 30 mM glucose and 0.1 mM palmitic acid (P0500, Sigma-Aldrich, USA) dissolved in 0.5% bovine serum albumin (BSA) for 48 h to simulate HGHF treatment. The Akt inhibitor MK-2206 2HCl was purchased from Selleck Chemicals (S1078, Houston, TX, USA).
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:22:17.348.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhihao Shu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-14 04:30:38	ID requested
⏵ 1	2022-08-12 00:22:18	announced

Shu Z, Chen S, Xiang H, Wu R, Wang X, Ouyang J, Zhang J, Liu H, Chen AF, Lu H, AKT/PACS2 Participates in Renal Vascular Hyperpermeability by Regulating Endothelial Fatty Acid Oxidation in Diabetic Mice. Front Pharmacol, 13():876937(2022) [pubmed]

submitter keyword: Vascular permeability, Diabetes, PACS2, fatty acid oxidation, endoplasmic reticulum, mitochondria, endothelial cell

Zhihao Shu
contact affiliation	1 Health Management Center, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China; 2 Department of Cardiology, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China;
contact email	zhihaoshu@126.com
lab head
Zhihao Shu
contact affiliation	The Third Xiangya Hospital
contact email	zhihaoshu@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD033227

PRIDE project URI

• PRIDE
  1. PXD033227
     1. Label: PRIDE project
     2. Name: AKT/PACS2 participates in renal vascular hyperpermeability by regulating endothelial fatty acid oxidation in diabetic mice