PXD033223

PXD033223 is an original dataset announced via ProteomeXchange.

Title	CK1 promotes double-strand break repair in fission yeast
Description	CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. The C-termini of these enzymes are thought to inhibit kinase activity by acting as pseudosubstrates. We were interested in identifying substrates of the fission yeast CK1 homologues Hhp1 and Hhp2, particularly substrates involved in DNA repair. We used quantitative phosphoproteomics to identify potential substrates of Hhp1 and Hhp2 in Schizosaccharomyces pombe and to compare between the full-length and C-terminally truncated forms.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_08:54:17.717.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jose Navarrete Perea
SpeciesList	scientific name: Schizosaccharomyces pombe; NCBI TaxID: 4896;
ModificationList	phosphorylated residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-14 04:23:53	ID requested
⏵ 1	2025-05-06 08:54:18	announced

Cullati SN, Akizuki K, Shan Y, Zhang E, Ren L, Guillen RX, Turner LA, Chen JS, Navarrete-Perea J, Elmore ZC, Gygi SP, Gould KL, The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex. Mol Cell Biol, 44(12):562-576(2024) [pubmed]

10.1080/10985549.2024.2408016;

submitter keyword: casein kinase 1,CK1, kinase substrates, S. pombe, kinase regulation

Kathleen L. Gould, Ph.D.
contact affiliation	Louise B. McGavock Professor Department of Cell and Developmental Biology Senior Associate Dean for Biomedical Research, Education and Training Vanderbilt University School of Medicine
contact email	kathy.gould@vanderbilt.edu
lab head
Jose Navarrete Perea
contact affiliation	Harvard Medical School
contact email	Jose_Navarrete-Perea@hms.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD033223

PRIDE project URI

• PRIDE
  1. PXD033223
     1. Label: PRIDE project
     2. Name: CK1 promotes double-strand break repair in fission yeast