PXD033222

PXD033222 is an original dataset announced via ProteomeXchange.

Title	Combinatorial screening of biological degrader modules to destroy intractable proteins – Kinetic Data
Description	Abstract – kinetic data Targeted protein degradation is a potent strategy against intracellular proteins impervious to traditional drugs. We describe a platform reliant on high-throughput cloning and mRNA-based delivery to quickly screen 100s-1000s modular biological degraders which we challenge against the intractable and high-turnover c-Myc oncoprotein. We uncover critical principles to drive the discovery of degraders against any target, capable of operating without prior cell line engineering, with direct applications in research and potentially therapy.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:49:57.085.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	SonjaHess
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-14 04:23:35	ID requested
⏵ 1	2023-11-14 06:49:57	announced

Dataset with its publication pending

submitter keyword: trim21, DIA-MS,timsTOF, kinetic data, spectronaut, Protac

SonjaHess
contact affiliation	Senior Director, Dynamic Omics, CGR, One Medimmune Way Gaithersburg, MD 20878
contact email	Sonja.Hess@astrazeneca.com
lab head
SonjaHess
contact affiliation	Dynamic Omics, CGR, Discovery Sciences, AstraZeneca
contact email	sonja.hess@astrazeneca.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD033222

PRIDE project URI

• PRIDE
  1. PXD033222
     1. Label: PRIDE project
     2. Name: Combinatorial screening of biological degrader modules to destroy intractable proteins – Kinetic Data