PXD033197 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A mechanism of gene evolution generating mucin function |
Description | How novel gene functions evolve is a fundamental question in biology. Mucin proteins, a functionally but not evolutionarily defined group of proteins, allow to study convergent evolution of gene function. By analyzing the genomic variation of mucins across a wide range of mammalian genomes, we propose that exonic repeats and their copy number variation contribute substantially to the de novo evolution of new gene functions. By integrating bioinformatic, phylogenetic, proteomic, and immunohistochemical approaches, we identified 15 undescribed instances of evolutionary convergence, where novel mucins originated by gaining densely O-glycosylated exonic repeat domains. Our results suggest that secreted proteins rich in proline are natural precursors for acquiring mucin function. Our findings have broad implications for understanding the role of exonic repeats in the parallel evolution of new gene functions, especially those involving protein glycosylation. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:33:06.416.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shichen Shen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Mustela putorius furo (European domestic ferret) (Mustela furo); NCBI TaxID: 9669; scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: 9615; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-13 02:56:04 | ID requested | |
1 | 2022-10-14 21:06:39 | announced | |
⏵ 2 | 2023-11-14 08:33:07 | announced | 2023-11-14: Updated project metadata. |
Publication List
Pajic P, Shen S, Qu J, May AJ, Knox S, Ruhl S, Gokcumen O, A mechanism of gene evolution generating mucin function. Sci Adv, 8(34):eabm8757(2022) [pubmed] |
Keyword List
submitter keyword: adaptation, convergent evolution, O-glycosylation, saliva, neofunctionalization,mucins, genomic structural variants, sub-exonic repeats, parallel evolution |
Contact List
Jun Qu |
contact affiliation | Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo |
contact email | junqu@buffalo.edu |
lab head | |
Shichen Shen |
contact affiliation | University at Buffalo |
contact email | shichens@buffalo.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033197
- Label: PRIDE project
- Name: A mechanism of gene evolution generating mucin function