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PXD033197

PXD033197 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA mechanism of gene evolution generating mucin function
DescriptionHow novel gene functions evolve is a fundamental question in biology. Mucin proteins, a functionally but not evolutionarily defined group of proteins, allow to study convergent evolution of gene function. By analyzing the genomic variation of mucins across a wide range of mammalian genomes, we propose that exonic repeats and their copy number variation contribute substantially to the de novo evolution of new gene functions. By integrating bioinformatic, phylogenetic, proteomic, and immunohistochemical approaches, we identified 15 undescribed instances of evolutionary convergence, where novel mucins originated by gaining densely O-glycosylated exonic repeat domains. Our results suggest that secreted proteins rich in proline are natural precursors for acquiring mucin function. Our findings have broad implications for understanding the role of exonic repeats in the parallel evolution of new gene functions, especially those involving protein glycosylation.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:33:06.416.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShichen Shen
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Mustela putorius furo (European domestic ferret) (Mustela furo); NCBI TaxID: 9669; scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: 9615;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-13 02:56:04ID requested
12022-10-14 21:06:39announced
22023-11-14 08:33:07announced2023-11-14: Updated project metadata.
Publication List
Pajic P, Shen S, Qu J, May AJ, Knox S, Ruhl S, Gokcumen O, A mechanism of gene evolution generating mucin function. Sci Adv, 8(34):eabm8757(2022) [pubmed]
Keyword List
submitter keyword: adaptation, convergent evolution, O-glycosylation, saliva, neofunctionalization,mucins, genomic structural variants, sub-exonic repeats, parallel evolution
Contact List
Jun Qu
contact affiliationDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo
contact emailjunqu@buffalo.edu
lab head
Shichen Shen
contact affiliationUniversity at Buffalo
contact emailshichens@buffalo.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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