PXD033153

PXD033153 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Dysregulated proteins in aqueous humor from primary open angle glaucoma patients with clinical correlation
Description	Primary open angle glaucoma (POAG) presents as an irreversible optic neuropathy with corresponding visual field deficits and no other notable symptoms. The pathophysiology of POAG remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. This enables us to better understand pathological changes in POAG from a molecular perspective, and may reveal potential diagnostic molecular biomarkers in POAG. We are also interested in correlating differences in AH protein compositions with demographics and clinical severity in POAG patients.
HostingRepository	PRIDE
AnnounceDate	2024-05-23
AnnouncementXML	Submission_2024-05-23_00:13:05.012.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	SoFong Cam Ngan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-11 03:04:27	ID requested
⏵ 1	2024-05-23 00:13:05	announced

Publication List

10.1016/j.exer.2024.109887;
Choy DMY, Ang BCH, Adav SS, Zheng YB, Goh CJS, Wei J, Kumaran A, Chua CH, Gan NY, Sze SK, Yip LWL, Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma. Exp Eye Res, 243():109887(2024) [pubmed]

10.1016/j.exer.2024.109887;

Choy DMY, Ang BCH, Adav SS, Zheng YB, Goh CJS, Wei J, Kumaran A, Chua CH, Gan NY, Sze SK, Yip LWL, Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma. Exp Eye Res, 243():109887(2024) [pubmed]

Keyword List

submitter keyword: proteomics, TMT,primary open angle glaucoma, aqueous humor, LC-MS/MS

submitter keyword: proteomics, TMT,primary open angle glaucoma, aqueous humor, LC-MS/MS

Contact List

Darren Choy Mun Yoong
contact affiliation	Ophthalmology, Tan Tock Seng Hospital, Singapore
contact email	darren.choy@mohh.com.sg
lab head
SoFong Cam Ngan
contact affiliation	Nanyang Technological University
contact email	sfcngan@ntu.edu.sg
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD033153
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD033153

PRIDE project URI

Repository Record List

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