PXD033146

PXD033146 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantitative Proteome and Lysine Lactylome of Proteins within Pathological Site of Rotator Cuff Tendinopathy
Description	Lysine lactylation (Kla) is a newly discovered posttranslational modification showing the addition of an L-lactate-derived lactyl group to the lysine residue. Histone lactylation has been found to regulate the downstream genes expression involved in the process of infection clearance, homeostasis retore, and tumorigenesis. Like other metabolite mediated PTMs, which the cellular levels of these metabolites affect the stoichiometry of the corresponding PTMs, the level of Kla also responds to the intracellular lactate concentration in a dose-dependent fashion associated with glycolysis metabolism. It has long been noted that manipulation of glycolysis metabolism could affect the tendon cell function, tendon homeostasis, and healing process of tendon.Nonetheless, the lactylation sites and regulations in tendinopathy remain unexplored.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:46:39.719.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuan Lin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-11 02:47:22	ID requested
1	2023-05-10 13:33:58	announced
⏵ 2	2023-11-14 08:46:43	announced	2023-11-14: Updated project metadata.

Publication List

Lin Y, Chen M, Wang D, Yu Y, Chen R, Zhang M, Yu H, Huang X, Rao M, Wang Y, Li Y, Yan J, Yin P, Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy. J Proteome Res, 22(6):1712-1722(2023) [pubmed]

Lin Y, Chen M, Wang D, Yu Y, Chen R, Zhang M, Yu H, Huang X, Rao M, Wang Y, Li Y, Yan J, Yin P, Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy. J Proteome Res, 22(6):1712-1722(2023) [pubmed]

Keyword List

submitter keyword: RCT;tendon
lysine lactylation;LC MS/MS

submitter keyword: RCT;tendon

lysine lactylation;LC MS/MS

Contact List

Pengbin Yin
contact affiliation	Department of Orthopedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, China National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, China
contact email	yinpengbin@gmail.com
lab head
Yuan Lin
contact affiliation	Harbin Medical University
contact email	ortholin@126.com
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD033146

PRIDE project URI

Repository Record List

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