PXD033137

PXD033137 is an original dataset announced via ProteomeXchange.

Title	Highly Active CAR T Cells that Bind to a Juxta-Membrane Region of Mesothelin and are Not Blocked by Shed Mesothelin
Description	Identification of the major protease sites in MSLN and preparation of a monoclonal antibody, 15B6, that binds next to cell membrane at the protease sensitive region and inhibits MSLN shedding. Mab 15B6 makes very active CAR-T cells whose activity is not blocked by shed MSLN. The 15B6 CAR-T cells have greatly superior anti-tumor activity in mice than CAR-T cells targeting an epitope in shed MSLN.
HostingRepository	PRIDE
AnnounceDate	2022-04-13
AnnouncementXML	Submission_2022-04-13_03:30:17.531.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Asif Shajahan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-11 01:30:30	ID requested
⏵ 1	2022-04-13 03:30:17	announced

Dataset with its publication pending

submitter keyword: immunotherapy, cancer, antibody, pancreatic cancer, ovarian cancer

Parastoo Azadi
contact affiliation	Technical Director Complex Carbohydrate Research Center 315 Riverbend Road Athens, Georgia 30602-4712 United States
contact email	azadi@uga.edu
lab head
Asif Shajahan
contact affiliation	Complex Carbohydrate Research Center
contact email	asifklm@uga.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD033137

PRIDE project URI

• PRIDE
  1. PXD033137
     1. Label: PRIDE project
     2. Name: Highly Active CAR T Cells that Bind to a Juxta-Membrane Region of Mesothelin and are Not Blocked by Shed Mesothelin