PXD033037

PXD033037 is an original dataset announced via ProteomeXchange.

Title	Low-dose anti-HIV drug efavirenz mitigates retinal vascular lesions in a mouse model of Alzheimer’s disease
Description	A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice(a mouse model foe Alzheimers disease. Herein, we investigated the retina of these animals, which were found to have genetically determined retinal vascular lesions associated with deposits within the retinal pigment epithelium and sub retinal space.. Thus gain an unbiased insight into the processes in the retina that could be to affected by efavirenz treatment, the proteomic approach was used to compare the retinas of efavirenz -treated and control 5XFAD mice.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:37:09.303.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD033037
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	NICOLE EL-DARZI
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-07 02:44:20	ID requested
1	2022-05-27 14:09:24	announced
⏵ 2	2024-10-22 05:37:09	announced	2024-10-22: Updated project metadata.

10.6019/PXD033037;

submitter keyword: Mus musculus retina

Irina A. Pikuleva
contact affiliation	Department of Ophthalmology and Visual Sciences, Case Western reserve University,Cleveland,OH,USA
contact email	iap8@case.edu
lab head
NICOLE EL-DARZI
contact affiliation	Case Werstern Reserve University
contact email	nae20@case.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD033037

PRIDE project URI

• PRIDE
  1. PXD033037
     1. Label: PRIDE project
     2. Name: Low-dose anti-HIV drug efavirenz mitigates retinal vascular lesions in a mouse model of Alzheimer’s disease