PXD033034

PXD033034 is an original dataset announced via ProteomeXchange.

Title	Large-scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis
Description	Neurosyphilis (NS) is a central nervous system infection caused by Treponema pallidum. NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imitator”, NS can be easily overlooked or misdiagnosed due to the absence of standard diagnostic tests, potentially leading to severe and irreversible organ dysfunction. In this study, proteomic and machine learning model techniques were used to characterize 223 cerebrospinal fluid (CSF) samples to identify diagnostic markers of NS and provide insights into the underlying mechanisms of the associated inflammatory responses. Three biomarkers (SEMA7A, SERPINA3, and ITIH4) were validated as contributors to NS diagnosis through multicenter verification of an additional 115 CSF samples. We anticipate that the identified biomarkers will become effective tools for assisting in diagnosis of NS. Our insights into NS pathogenesis in brain tissue may inform therapeutic strategies and drug discoveries for NS patients.
HostingRepository	iProX
AnnounceDate	2024-02-16
AnnouncementXML	Submission_2024-02-17_22:46:29.397.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Ma
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-06 20:30:12	ID requested
1	2024-02-17 22:37:35	announced
⏵ 2	2024-02-17 22:46:29	announced	2024-02-18: Update information.

Dataset with its publication pending

submitter keyword: Cerebrospinal fluid, diagnostic biomarker, machine learning model, neurosyphilis, proteomics

Ling Leng
contact affiliation	Peking Union Medical College Hospital
contact email	lengling@pumch.cn
lab head
Jie Ma
contact affiliation	National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
contact email	majie@ncpsb.org.cn
dataset submitter

iProX dataset URI