PXD032997

PXD032997 is an original dataset announced via ProteomeXchange.

Title	Stool metaproteomics of children with islet autoimmunity
Description	The gastrointestinal ecosystem is a highly complex environment with a profound influence on human health. Inflammation in the gut, linked to an altered gut microbiome has been associated with the development of multiple human conditions including type 1 diabetes (T1D). Viruses infecting the gastrointestinal tract, especially enteroviruses, are also thought to play an important role in T1D pathogenesis possibly via overlapping mechanisms. Here, we apply an integrative approach to combine comprehensive faecal virome, microbiome and metaproteome data sampled before and at the onset of islet autoimmunity in 40 children. We show strong age and antibody related effects across the datasets. Mastadenovirus infection was associated with profound functional changes in the faecal metaproteome. Multiomic factor analysis modelling revealed proteins associated with carbohydrate transport from the genus Faecalibacterium were associated with islet autoimmunity. These findings demonstrate functional remodelling of the gut microbiota accompanies both islet autoimmunity and viral infection.
HostingRepository	PRIDE
AnnounceDate	2022-08-22
AnnouncementXML	Submission_2022-08-22_07:03:57.365.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	patrick gavin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-06 01:27:52	ID requested
⏵ 1	2022-08-22 07:03:57	announced

Dataset with its publication pending

submitter keyword: T1D metaproteome

Emma Hamilton Williams
contact affiliation	Univeristy of Queensland
contact email	e.hamiltonwilliams@uq.edu.au
lab head
patrick gavin
contact affiliation	university of queensland
contact email	pgavin8@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032997
     1. Label: PRIDE project
     2. Name: Stool metaproteomics of children with islet autoimmunity