PXD032981

PXD032981 is an original dataset announced via ProteomeXchange.

Title	Integrating multi-omics analyses unveil protein features of gestational diabetes mellitus and preeclampsia
Description	As one of the most common maternal comorbidities, gestational diabetes mellitus (GDM) and preeclampsia (PE) are associated with maternal and infant health. Although the pathogenesis of PE and GDM remains controversial, oxidative stress is thought to be involved in the underlying pathology of GDM and PE. Protein lysine acetylation (Kac) plays an important regulatory role in biological processes. There is little data regarding the association of the maternal acetylome with GDM and PE. This study aimed to assess the multi-omics (proteome and acetylome) potential value in the underlying pathology for GDM and PE by label-free quantification proteomics technology. In our study, we included placental tissue from healthy individuals (n=6), GDM patients (n=6), and PE patients (n=6). We identified 22 overlapping DEPs (differentially expressed proteins) and 192 overlapping DAPs (differentially acetylated proteins) between the GDM and PE groups. Furthermore, 192 overlapping DAPs were mainly enriched in endoplasmic reticulum stress and ferroptosis pathways. Interestingly, endoplasmic reticulum stress, ferroptosis, and oxidative stress are believed to be related to each other. We also identified that acetylation of the HSP90AA1, HSPA8, PDIA3, GPX4, TF, and CP might serve as novel markers and better therapeutic targets in both complications. We thoroughly analyzed the key characteristics of proteome and acetylome in GDM and PE placental tissues, which may be useful for exploring the underlying pathology and discovering new biomarkers and therapeutic targets.
HostingRepository	PRIDE
AnnounceDate	2024-01-25
AnnouncementXML	Submission_2024-01-25_02:57:44.406.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Biying Hu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	autoflex

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-03 08:42:39	ID requested
⏵ 1	2024-01-25 02:57:47	announced

10.1002/pmic.202200124;

Hu B, Li D, Tang D, Shangguan Y, Cao Y, Guo R, Luan S, Yun C, Morgera S, Hocher B, Kr, ä, mer BK, Wang Y, Yin L, Dai Y, Integrated proteome and acetylome analyses unveil protein features of gestational diabetes mellitus and preeclampsia. Proteomics, 22(22):e2200124(2022) [pubmed]

submitter keyword: lysine acetylation, proteomics,Gestational diabetes mellitus, preeclampsia, oxidative stress

Yong Dai
contact affiliation	The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, China
contact email	daiyong22@aliyun.com
lab head
Biying Hu
contact affiliation	The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, China.
contact email	hubiyingjy@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032981
     1. Label: PRIDE project
     2. Name: Integrating multi-omics analyses unveil protein features of gestational diabetes mellitus and preeclampsia