PXD032969

PXD032969 is an original dataset announced via ProteomeXchange.

Title	Plasma proteome profiling of healthy subjects undergoing bed rest reveals unload-dependent changes linked to muscle atrophy.Plasma proteome profiling of healthy subjects undergoing bed rest reveals unload-dependent changes linked to muscle atrophy.
Description	Inactivity and unloading. induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. We used mass spectrometry-based proteomics to measure the abundance changes of proteins circulating in the blood plasma of young healthy subject undergoing ten days of continuous bed rest. Several plasma components, such as the complement cascade and lipid carriers, and proteins derived from the extracellular matrix and tissue leakage, such as lumican and teneurin-4, changed their abundance at different loading states of the body. Searching for potential plasma biomarkers relaying changes in muscle trophism, we identify common proteomic signatures distinguishing the majority of subjects undergoing extensive unloading-mediated muscle atrophy from those largely maintaining their initial muscle mass at the end of bed rest. Some of these plasma proteins also have different abundance in the serum proteome of cancer patients developing cachexia compared to that of healthy controls. Our findings highlight a combination or proteomic changes that can be explored as potential biomarkers of muscle atrophy occurring under different conditions.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:42:45.025.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marta Murgia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-03 07:36:41	ID requested
1	2023-03-11 04:24:05	announced
⏵ 2	2023-11-14 08:42:52	announced	2023-11-14: Updated project metadata.

Murgia M, Brocca L, Monti E, Franchi MV, Zwiebel M, Steigerwald S, Giacomello E, Sartori R, Zampieri S, Capovilla G, Gasparini M, Biolo G, Sandri M, Mann M, Narici MV, Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading-dependent changes linked to muscle atrophy. J Cachexia Sarcopenia Muscle, 14(1):439-451(2023) [pubmed]

submitter keyword: bed rest,proteomics, plasma, skeletal muscle, cachexia, atrophy

Marta Murgia
contact affiliation	Department of Proteomics and Signal Transduction Max-Planck-Institute of Biochemistry Am Klopferspitz 1882152 Martinsried, Germany AND Department of Biomedical Sciences, University of Padova, Via Ugo Bassi, 58/B, 35131, Padua Italy
contact email	mmurgia@biochem.mpg.de
lab head
Marta Murgia
contact affiliation	MPI Biochemistry
contact email	mmurgia@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD032969

PRIDE project URI

• PRIDE
  1. PXD032969
     1. Label: PRIDE project
     2. Name: Plasma proteome profiling of healthy subjects undergoing bed rest reveals unload-dependent changes linked to muscle atrophy.Plasma proteome profiling of healthy subjects undergoing bed rest reveals unload-dependent changes linked to muscle atrophy.