PXD032949

PXD032949 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Myocardial Injury Caused by Chronic Alcohol Exposure——A Pilot Study Based on Proteomic
Description	Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are defined as alcoholic cardiomyopathy (ACM). Alcohol-mediated myocardial injury has previously been studied through metabolomics, and it has been proved to be involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway related to the biosynthesis of unsaturated fatty acids and oxidative phosphorylation, which tentatively explored the mechanism of ACM induced by chronic drinking. To further study the myocardial damage caused by alcohol, the mouse model of ACM successfully established previously was used to perform proteomics analysis on myocardial specimens. Fifty-six differentially expressed proteins (DEPs) were identified, and they are involved in the KEGG pathway related to fatty acid biosynthesis, lipid metabolism, oxidative stress, and the development of dilated cardiomyopathy (DCM). The present study further demonstrated the underlying causes of myocardial damage caused by chronic alcohol consumption and lays the foundation for further research to clarify the underlying mechanism of ACM.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:14:59.303.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaonan Ma
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	(18)O label at both C-terminal oxygens
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-02 14:21:04	ID requested
⏵ 1	2022-08-12 00:15:00	announced

Publication List

Ma X, Liao Z, Li R, Xia W, Guo H, Luo J, Sheng H, Tian M, Cao Z, Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics. Molecules, 27(13):(2022) [pubmed]

Ma X, Liao Z, Li R, Xia W, Guo H, Luo J, Sheng H, Tian M, Cao Z, Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics. Molecules, 27(13):(2022) [pubmed]

Keyword List

submitter keyword: alcoholic cardiomyopathy
proteomics
differentially expressed proteins
KEGG pathway
myocardial injury

submitter keyword: alcoholic cardiomyopathy

proteomics

differentially expressed proteins

KEGG pathway

myocardial injury

Contact List

Zhipeng Cao
contact affiliation	China Medical University School of Forensic Medicine
contact email	zpcao@cmu.edu.cn
lab head
Xiaonan Ma
contact affiliation	China Medical University
contact email	1158192730@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD032949
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD032949

PRIDE project URI

Repository Record List

[ + ]