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PXD032914

PXD032914 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlecomparative proteomics and elemental analysis reveal molecular adaption of Mollusca radula to different lifestyles
DescriptionRadula is a unique foraging organ to Mollusca, which is important for their evolution and taxonomic classification. Many radulae are mineralized with metals. Although the remarkable mechanical properties of mineralized radula are well-studied, the formation of mineralization from nonmineralized radula is poorly understood. Taking advantage of the recently sequenced octopus and chiton genome, we were able to identify more species-specific radula proteins by proteomics. Comparing these proteomes enable us to gain insight into the molecular components of nonmineralized and mineralized radula, highlighting that iron mineralization in chiton radula is possibly due to the evolution of ferritins and peroxiredoxins. Through in vitro binding assay, ferritin is shown to be important to iron accumulation into the nonmineralized radula. Moreover, radula proteomes are well adapted to their functionality. Octopus radula has many scaffold modification proteins to suit flexibility while chiton radula has abundant sugar metabolism proteins (e.g. glycosyl hydrolases) to adapt to algae feeding. This study provides a foundation for the understanding of Mollusca radula formation and evolution and may inspire the synthesis of iron nanomaterials.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:16:56.800.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChuang Liu
SpeciesList scientific name: Octopus variabilis; NCBI TaxID: 158018;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-02 11:44:52ID requested
12022-10-27 03:28:25announced
22023-11-14 08:16:57announced2023-11-14: Updated project metadata.
Publication List
Liu C, Sun D, Chen Y, Wang C, Li J, Lin J, Mineralize It or Not: Comparative Proteomics and Elemental Analysis Reveal Ancestral Compositions of Iron Mineralized Molluscan Radulae. J Proteome Res, 21(11):2736-2742(2022) [pubmed]
Keyword List
submitter keyword: Mollusca
Radula
Proteomics
Iron mineralization
Ferritin
Contact List
Chuang Liu
contact affiliationHohai university, China
contact emailhelloliuchuang@163.com
lab head
Chuang Liu
contact affiliationHohai University, Nanjing, China
contact emailhelloliuchuang@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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