PXD032912

PXD032912 is an original dataset announced via ProteomeXchange.

Title	Proteome Profiling Identifies Serum Biomarkers in Rheumatoid Arthritis
Description	Rheumatoid arthritis (RA) causes serious disability and productivity loss, and there is an urgent need for appropriate biomarkers for diagnosis, treatment assessment, and prognosis evaluation. To identify serum markers of RA, we performed mass spectrometry (MS)-based proteomics, and we obtained 24 important markers in normal and RA patient samples using a random forest machine learning model and 11 protein-protein interaction (PPI) network topological analysis methods. Re-analyze markers using additional proteomics datasets, immune infiltration status, tissue specificity, subcellular localization, correlation analysis with disease activity-based diagnostic indications, diagnostic receiver-operating characteristic analysis We discovered that ORM1 in serum is significantly differentially expressed in normal and RA patient samples, which is positively correlated with disease activity, and is closely related to CD56dim natural killer cell, effector memory CD8+ T cell and natural killer cell in the pathological mechanism, which can be better utilized for diagnosis, monitoring disease progression and efficacy assessment. This study supplies a comprehensive strategy for discovering potential serum biomarkers of RA, and provides a different perspective for comprehending the pathological mechanism of RA, identifying potential therapeutic targets, and disease management.
HostingRepository	PRIDE
AnnounceDate	2022-04-19
AnnouncementXML	Submission_2022-04-19_06:59:07.577.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	congqi hu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	6220 Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-02 11:42:01	ID requested
⏵ 1	2022-04-19 06:59:07	announced

Dataset with its publication pending

submitter keyword: rheumatoid arthritis

biomarker

proteomics

ORM1

Congqi Hu
contact affiliation	Department of Rheumatology, First Affiliated Hospital of Guangzhou University of Chinese Medicine,China
contact email	congqihu@126.com
lab head
congqi hu
contact affiliation	Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
contact email	congqihu@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD032912

PRIDE project URI

• PRIDE
  1. PXD032912
     1. Label: PRIDE project
     2. Name: Proteome Profiling Identifies Serum Biomarkers in Rheumatoid Arthritis