PXD032899

PXD032899 is an original dataset announced via ProteomeXchange.

Title	Development and validation of a secretome-specific prognostic and predictive gene expression signature for colorectal cancer
Description	Relapse and metastatic progression is a frequent event in colorectal cancer patients detected at early stages. The risk of recurrence requires the development of new biomarkers to correctly predict biological behavior of early stage II and stage III patients and their response to adjuvant chemotherapy. Here, we combined the proteomic quantification of secreted proteins involved in metastasis with a transcriptional analysis to develop a risk score algorithm based on the expression of six genes (SEC6). The SEC6 signature was predictive of survival and recurrence for stage II and III patients in four different datasets including a total of 1534 patients and was also associated with deficient mismatch repair, CpG-island methylator positive status and BRAF mutation. SEC6 was also predictive of beneficial or detrimental effects from 5-Fluorouracil-containing regimes and the improved response to more aggressive chemotherapies based on FOLFOX and FOLFIRI. In summary, the SEC6 risk-score algorithm may constitute a new tool for decision-making in colorectal cancer management.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:55:55.971.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vivian de los Rios
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-02 02:50:52	ID requested
1	2023-01-04 03:59:27	announced
⏵ 2	2023-11-14 08:55:56	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: prognostic signature, stage stratification, secreted proteins,Colorectal cancer, metastasis

Jose Ignacio Casal
contact affiliation	Department of Molecular Biomedicine. Centro de Investigaciones Biológicas Margarita Salas. CSIC.
contact email	icasal@cib.csic.es
lab head
Vivian de los Rios
contact affiliation	CIB.CSIC
contact email	vrios@cib.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD032899

PRIDE project URI

• PRIDE
  1. PXD032899
     1. Label: PRIDE project
     2. Name: Development and validation of a secretome-specific prognostic and predictive gene expression signature for colorectal cancer