PXD032898

PXD032898 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The protein profiles of neural stem cells
Description	Stemazole was reported to induce the survival of human neural stem cells in the absence of growth factors and to have therapeutic effects on neurodegenerative diseases. However, the molecular mechanisms of stemazole against apoptosis are ambiguous. In this study, tandem mass tag (TMT)-based proteomics was performed to obtain whole protein expression profiles of human neural stem cells in different groups, which was performed with or without stemazole and under extreme conditions. Bioinformatics analysis based on protein–protein interaction (PPI) network construction, gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis were adopted to explore crucial proteins and possible pharmaco-logical mechanisms. A total of 77 differentially expressed proteins were identified, comprising 38 upregulated proteins and 39 downregulated proteins. FN1(Fibronectin), Asparagine synthetase (ASNS), Phosphoserine aminotransferase (PSAT1), PKA C-alpha (PRKACA), Phospholipase C beta3 (PLCB
HostingRepository	iProX
AnnounceDate	2022-04-02
AnnouncementXML	Submission_2022-09-29_01:32:05.822.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mingzhu Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-01 22:25:43	ID requested
1	2022-04-01 22:25:52	announced
⏵ 2	2022-09-29 01:32:06	announced	2022-09-29: Update publication information.

Publication List

Chen M, Zhu Y, Li H, Zhang Y, Han M, A Quantitative Proteomic Approach Explores the Possible Mechanisms by Which the Small Molecule Stemazole Promotes the Survival of Human Neural Stem Cells. Brain Sci, 12(6):(2022) [pubmed]

Chen M, Zhu Y, Li H, Zhang Y, Han M, A Quantitative Proteomic Approach Explores the Possible Mechanisms by Which the Small Molecule Stemazole Promotes the Survival of Human Neural Stem Cells. Brain Sci, 12(6):(2022) [pubmed]

Keyword List

submitter keyword: quantitative proteomics, human neural stem cells, stemazole

submitter keyword: quantitative proteomics, human neural stem cells, stemazole

Contact List

Mei Han
contact affiliation	Beijing Normal University
contact email	hanmei@bnu.edu.cn
lab head
Mingzhu Chen
contact affiliation	Beijing Normal University
contact email	mingzhucc@126.com
dataset submitter

Full Dataset Link List

iProX dataset URI

iProX dataset URI