PXD032897
PXD032897 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome analysis reveals novel serum biomarkers for Henoch-Schönlein purpura in Chinese children |
| Description | We performed proteomic profiling on serum samples from HSP patients and healthy children using an approach combining magnetic bead-based weak cation exchange and matrix-assisted laser desorption ionization-time of flight mass spectrometry. We next performed liquid chromatography-electrospray ionization-tandem mass spectrometry to identify the proteins and selected potential biomarker based on bioinformatics analysis of the STRING and GO dataset. 7 peptides showing the most significant changes in abundance across HSP patients and healthy children patients, were identified as peptide regions of ALB C4A TUBB FGA and EZR. Validation studies and statistical analysis showed that high serum C4A, ALB and low serum EZR levels, high serum C4A and IgA levels, and high serum D-dimer levels as independent risk factors for HSP, HSP nephritis (HSPN), and abdominal HSP, respectively |
| HostingRepository | iProX |
| AnnounceDate | 2022-04-02 |
| AnnouncementXML | Submission_2023-12-25_19:59:29.472.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lily Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-04-01 21:14:49 | ID requested | |
| 1 | 2022-04-01 21:17:39 | announced | |
| ⏵ 2 | 2023-12-25 19:59:30 | announced | 2023-12-26: Update information. |
Publication List
| Liu L, Liu H, Zhu K, Zhang L, Yin X, Han L, Wang M, Gao S, Xiao X, Yang J, Huang C, Huang Y, nlein purpura in Chinese children. J Proteomics, 276():104841(2023) [pubmed] |
Keyword List
| submitter keyword: Early diagnosis, Henoch-Schönlein purpura, mass spectrometry, serum biomarker |
Contact List
| Chen Huang | |
|---|---|
| contact affiliation | Xi'an Jiaotong University |
| contact email | hchen@mail.xjtu.edu.cn |
| lab head | |
| Lily Liu | |
| contact affiliation | Xi'an Jiaotong University Medical College First Affiliated Hospital |
| contact email | lily@xjtufh.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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