PXD032894 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Sweat proteomic of cystic fibrosis patients |
Description | Sweat plays a crucial role in thermo-regulation and skin health and potentially antimicrobial defense. Its composition is highly dynamic and its homeostasis involves a fine tuning of metabolic pathways. In-depth profiling of sweat protein composition will increase our understanding of skin disorders. Cystic Fibrosis (CF) is associated with high NaCl sweat concentration due to the absence of the CFTR protein. Patients with CF (pwCF) often display aquagenic palmoplantar keratodermia, a rare skin disorder characterized by skin wrinkling with oedema and whitish papules on the palms and/or soles, the pathophysiology of which is unknown. We report an in-depth analysis of the human sweat proteome of pwCF patients in comparison with that of healthy subjects (S). |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:43:06.028.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD032894 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Chiara guerrera |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-01 09:42:18 | ID requested | |
1 | 2023-03-11 06:14:55 | announced | |
⏵ 2 | 2023-11-14 08:43:06 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD032894; |
Cornet M, Nguyen-Khoa T, Kelly-Aubert M, Jung V, Chedevergne F, Le Bourgeois M, Aoust L, Roger K, Guerrera CI, Sermet-Gaudelus I, Proteomic profiling of sweat in patients with cystic fibrosis provides new insights into epidermal homoeostasis. Skin Health Dis, 3(1):e161(2023) [pubmed] |
Keyword List
submitter keyword: CFTR,cystic fibrosis, sweat proteomic |
Contact List
Chiara Guerrera |
contact affiliation | Structure Fédérative de Recherche Necker, INSERM US24-CNRS UAR3633, Paris, France |
contact email | chiara.guerrera@inserm.fr |
lab head | |
Chiara guerrera |
contact affiliation | Necker proteomics, INSERM |
contact email | chiara.guerrera@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032894
- Label: PRIDE project
- Name: Sweat proteomic of cystic fibrosis patients