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PXD032894

PXD032894 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSweat proteomic of cystic fibrosis patients
DescriptionSweat plays a crucial role in thermo-regulation and skin health and potentially antimicrobial defense. Its composition is highly dynamic and its homeostasis involves a fine tuning of metabolic pathways. In-depth profiling of sweat protein composition will increase our understanding of skin disorders. Cystic Fibrosis (CF) is associated with high NaCl sweat concentration due to the absence of the CFTR protein. Patients with CF (pwCF) often display aquagenic palmoplantar keratodermia, a rare skin disorder characterized by skin wrinkling with oedema and whitish papules on the palms and/or soles, the pathophysiology of which is unknown. We report an in-depth analysis of the human sweat proteome of pwCF patients in comparison with that of healthy subjects (S).
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:43:06.028.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD032894
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterChiara guerrera
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-01 09:42:18ID requested
12023-03-11 06:14:55announced
22023-11-14 08:43:06announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD032894;
Cornet M, Nguyen-Khoa T, Kelly-Aubert M, Jung V, Chedevergne F, Le Bourgeois M, Aoust L, Roger K, Guerrera CI, Sermet-Gaudelus I, Proteomic profiling of sweat in patients with cystic fibrosis provides new insights into epidermal homoeostasis. Skin Health Dis, 3(1):e161(2023) [pubmed]
Keyword List
submitter keyword: CFTR,cystic fibrosis, sweat proteomic
Contact List
Chiara Guerrera
contact affiliationStructure Fédérative de Recherche Necker, INSERM US24-CNRS UAR3633, Paris, France
contact emailchiara.guerrera@inserm.fr
lab head
Chiara guerrera
contact affiliationNecker proteomics, INSERM
contact emailchiara.guerrera@inserm.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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