PXD032834

PXD032834 is an original dataset announced via ProteomeXchange.

Title	Interactome of PRMT5 in malaria parasite Plasmodium falciparum
Description	Protein arginine methyltransferases (PRMTs) modify proteins that cause their functional change by modulating their localization and interactions with their partners, which controls their functions on cellular processes, such as transcription and signal transduction, DNA repair, and RNA processing. The majority of studies on PRMTs are focused on yeast and mammals. We characterize PfPRMT5, a type II PRMT, from the early eukaryote Plasmodium falciparum. PfPRMT5 contains the conserved domain structures of type II enzyme with a diverse long N-terminus. This study revealed that PfPRMT5 associated with other invasion related transcriptional regulators such as AP2-I and BDP1. Furthermore, PfPRMT5 was associated with RNA splicing machinery, indicating that PfPRMT5 plays a critical role in regulating invasion and harbors conserved function in RNA metabolism.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:57:27.338.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD032834
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	JUN MIAO
SpeciesList	scientific name: Plasmodium falciparum (isolate 3D7); NCBI TaxID: 36329;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-26 14:41:29	ID requested
1	2023-06-28 07:42:59	announced
⏵ 2	2023-11-14 06:57:27	announced	2023-11-14: Updated project metadata.

10.6019/PXD032834;

submitter keyword: malaria, interactome, Plasmodium falciparum,protein arginine methyltransferase

Jun Miao
contact affiliation	Department of Internal Medicine, Morsani College of Medicine, University of South Florida
contact email	jmiao1@usf.edu
lab head
JUN MIAO
contact affiliation	University of Sourth Florida
contact email	jmiao1@usf.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032834
     1. Label: PRIDE project
     2. Name: Interactome of PRMT5 in malaria parasite Plasmodium falciparum