PXD032827 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of mouse liver with conditional knock-out of Cathepsin D in macrophages |
Description | The cell-specific role of lysosomal protease cathepsin D (CtsD) in liver fibrosis is not completely clear. This study reports that while CtsD is highly expressed in liver macrophages of cirrhotic patients, CtsD deletion in macrophages resulted in enhanced liver fibrosis. For this scope, a macrophage-CtsD knock-out mouse (CtsDMac) model was generated. Livers obtained from the mouse model and from its control were analyzed by shotgun label-free quantitative (LFQ) proteomics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:51:14.688.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michele Costanzo |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-26 14:19:37 | ID requested | |
1 | 2024-07-25 09:39:41 | announced | |
⏵ 2 | 2024-10-22 06:51:15 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: label-free proteomics, liver fibrosis,Cathepsin D, S-Trap |
Contact List
Michele Costanzo |
contact affiliation | Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Italy |
contact email | michele.costanzo@unina.it |
lab head | |
Michele Costanzo |
contact affiliation | Department of Molecular Medicine and Medical Biotechnology - University of Naples Federico II |
contact email | michele.costanzo@unina.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032827
- Label: PRIDE project
- Name: Proteomic analysis of mouse liver with conditional knock-out of Cathepsin D in macrophages