PXD032827

PXD032827 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of mouse liver with conditional knock-out of Cathepsin D in macrophages
Description	The cell-specific role of lysosomal protease cathepsin D (CtsD) in liver fibrosis is not completely clear. This study reports that while CtsD is highly expressed in liver macrophages of cirrhotic patients, CtsD deletion in macrophages resulted in enhanced liver fibrosis. For this scope, a macrophage-CtsD knock-out mouse (CtsDMac) model was generated. Livers obtained from the mouse model and from its control were analyzed by shotgun label-free quantitative (LFQ) proteomics.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:51:14.688.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michele Costanzo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-26 14:19:37	ID requested
1	2024-07-25 09:39:41	announced
⏵ 2	2024-10-22 06:51:15	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/J.MOLMET.2024.101989;

10.1016/J.MOLMET.2024.101989;

Keyword List

submitter keyword: label-free proteomics, liver fibrosis,Cathepsin D, S-Trap

submitter keyword: label-free proteomics, liver fibrosis,Cathepsin D, S-Trap

Contact List

Michele Costanzo
contact affiliation	Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Italy
contact email	michele.costanzo@unina.it
lab head
Michele Costanzo
contact affiliation	Department of Molecular Medicine and Medical Biotechnology - University of Naples Federico II
contact email	michele.costanzo@unina.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD032827
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD032827

PRIDE project URI

Repository Record List

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