PXD032814

PXD032814 is an original dataset announced via ProteomeXchange.

Title	Notoginsenoside R1 regulates ischemic myocardial lipid metabolism through activating AKT/mTOR signaling pathway
Description	Radix notoginseng is widely used to treat ischemic heart disease in China and other Asian countries, and notoginsenoside R1 (NGR1) is its characteristic and large-amount ingredient. However, the potential molecular mechanisms of NGR1 improving ischemic heart diseases are unclear. Our results revealed that NGR1 improved the echocardiographic, tissue pathological and serum biochemical perturbations in myocardial ischemic rats. The network pharmacology studies indicated that NGR1 mainly regulated smooth muscle cell proliferation, vasculature development and lipid metabolism signaling, especially PI3K/AKT pathway. The myocardial proteomics revealed that the function of NGR1 was focused on regulating metabolic progresses and energy supply processes. The combining research of reverse-docked targets and differential proteins demonstrated that NGR1 modulated lipid metabolism in ischemic myocardial and mTOR and AKT were key targets. Conventional MD simulation was adopted to investigate the interference effect of NGR1 on the structure stabilization of mTOR and AKT complex. The results suggested that NGR1 can strengthen the affinity stabilization of mTOR and AKT.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:11:32.348.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yanzhen Zhao
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-25 08:58:50	ID requested
⏵ 1	2022-08-12 00:11:33	announced

Lei W, Yan Y, Ma Y, Jiang M, Zhang B, Zhang H, Li Y, Notoginsenoside R1 Regulates Ischemic Myocardial Lipid Metabolism by Activating the AKT/mTOR Signaling Pathway. Front Pharmacol, 13():905092(2022) [pubmed]

submitter keyword: Notoginsenoside R1

ischemic heart disease

cardioprotection

lipid metabolism

AKT/mTOR pathway

Yuhong Li
contact affiliation	Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District,Tianjin 301617, China.
contact email	liyuhong@tjutcm.edu.cn
lab head
yanzhen Zhao
contact affiliation	shanghai
contact email	449096780@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032814
     1. Label: PRIDE project
     2. Name: Notoginsenoside R1 regulates ischemic myocardial lipid metabolism through activating AKT/mTOR signaling pathway