PXD032807
PXD032807 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The novels biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis |
Description | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Continuous renal replacement therapy (CRRT) is regarded as an adjuvant therapy for critically ill, which removes excess fluids and clear uremic toxins, endotoxins, proteins, and inflammatory mediators efficiently. In patients with sepsis, CRRT has the advantages of maintaining hemodynamic stability, accurate fluid control, and steady acid-base and electrolyte correction. 2020 “Surviving Sepsis Campaign (SSC) international guidelines” for children suggested that CRRT should be considered in hemodynamically unstable septic patients for promoting management of fluid balance and acute kidney injury (AKI).Blood levels of cytokines (such as interleukin-8 [IL-8], tumor necrosis factor -α [TNF-α], IL-10, and IL-6) and endotoxins are often elevated in patients with sepsis. CRRT removing endotoxins and cytokines from septic patients is associated with improved patient outcomes. Our previous multicenter study indicated th |
HostingRepository | iProX |
AnnounceDate | 2022-03-25 |
AnnouncementXML | Submission_2023-01-28_19:52:03.851.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shuyun Feng |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-03-25 01:56:15 | ID requested | |
1 | 2022-03-25 01:56:33 | announced | |
⏵ 2 | 2023-01-28 19:52:04 | announced | 2023-01-29: Update publication information. |
Publication List
Cui Y, Feng S, Miao H, Liu T, Shi J, Dou J, Wang C, Zhang Y, The novel biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis: a pilot study. Clin Proteomics, 20(1):4(2023) [pubmed] |
Keyword List
submitter keyword: continuous renal replacement therapy, pediatric sepsis, biomarkers |
Contact List
Chunxia Wang | |
---|---|
contact affiliation | Shanghai Children Hospital, Shanghai Jiao Tong University School of Medicine |
contact email | karencx0465@163.com |
lab head | |
Shuyun Feng | |
contact affiliation | Shanghai Children Hospital, Shanghai Jiao Tong University School of Medicine |
contact email | fengshuyun2020@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |