PXD032767

PXD032767 is an original dataset announced via ProteomeXchange.

Title	Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis
Description	Brain metastases are critical for outcomes and quality of life in almost 50% of oncological patients, generally associated with a poor short-term prognosis. Early or preventive diagnosis of this complication represents an unmet need. There is a necessity of discovering new biomarkers that could aid to predict disease outcome. In this study, we analyzed plasma circulating extracellular vesicles (EVs) from a cohort of 92 patients with different solid tumors (lung, breast, kidney cancer and melanoma) and found that newly diagnosed patients with brain metastases presented lower number of circulating particles and a higher protein concentration in small extracellular vesicles (sEVs) compared to patients without brain metastases and healthy controls. Out of all groups analyzed, melanoma patients with brain metastases presented decreased STAT3 activation and increased PD-L1 levels in circulating sEVs compared to patients without central nervous system metastases. The data presented in this work suggest that circulating sEVs may represent the immunosuppressive status of newly diagnosed brain metastases characterized by the reduced phospho-STAT3 (pSTAT3) and increased PD-L1, although the origin of these molecules found in circulating sEVs remains to be uncovered.
HostingRepository	PRIDE
AnnounceDate	2022-05-08
AnnouncementXML	Submission_2022-05-08_05:38:53.949.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pilar Ximenez-Embun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-23 08:18:32	ID requested
1	2022-05-08 03:44:53	announced
⏵ 2	2022-05-08 05:38:54	announced	2022-05-08: Updated publication reference for PubMed record(s): 35481283.

Carretero-Gonz, á, lez A, Hergueta-Redondo M, S, á, nchez-Redondo S, Xim, é, nez-Emb, ú, n P, Manso S, á, nchez L, Gil EC, Castellano D, de Velasco G, Peinado H, Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis. Oncoimmunology, 11(1):2067944(2022) [pubmed]

submitter keyword: human, brain metastasis, exosomes, plasma

Pilar Ximénez-Embún
contact affiliation	Proteomics Unit Spanish National Cancer Research Centre (CNIO) ProteoRed-ISCIII Melchor Férnandez Almagro, 3 28029 Madrid. SPAIN
contact email	mpximenez@cnio.es
lab head
Pilar Ximenez-Embun
contact affiliation	Proteomics Group
contact email	mpximenez@cnio.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032767
     1. Label: PRIDE project
     2. Name: Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis