PXD032757

PXD032757 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The role of extracellular vesicles in synovial fibroblast senescence
Description	In arthritis, synovial fibroblast (SF) senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. Additionally, senescent cells accumulate in ageing tissues further promoting ageing and inflammation. These cells have dysregulated mitochondrial function and metabolism, limited tissue regeneration, produce reactive oxygen species (ROS) and secrete bioactive molecules, including pro-inflammatory cytokines, chemokines and matrix-remodelling enzymes known as SASP (senescence-associated secretory phenotype). In vitro, senescent cells can induce a senescent phenotype in surrounding bystander cells. Interestingly, extracellular vesicles (EVs) have critical roles in cellular senescence and ageing and are mediators in intercellular communication. We hypothesize that senescent cells in osteoarthritic SFs induce senescence and/or a proinflammatory phenotype in non-senescent osteoarthritic SFs, mediated through EV cargo.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:26:08.667.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD032757
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	James Anderson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-23 08:04:29	ID requested
1	2022-10-14 19:43:15	announced
⏵ 2	2023-11-14 08:26:14	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD032757;
Wijesinghe SN, Anderson J, Brown TJ, Nanus DE, Housmans B, Green JA, Hackl M, Choi KK, Arkill KP, Welting T, James V, Jones SW, Peffers MJ, The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence. Front Mol Biosci, 9():971621(2022) [pubmed]

10.6019/PXD032757;

Wijesinghe SN, Anderson J, Brown TJ, Nanus DE, Housmans B, Green JA, Hackl M, Choi KK, Arkill KP, Welting T, James V, Jones SW, Peffers MJ, The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence. Front Mol Biosci, 9():971621(2022) [pubmed]

Keyword List

submitter keyword: Human, Extracellular Vesicles, Synovial Fibroblasts, LC-MS/MS

submitter keyword: Human, Extracellular Vesicles, Synovial Fibroblasts, LC-MS/MS

Contact List

Mandy Jayne Peffers
contact affiliation	University of Liverpool, Institute of Life Course and Medical Sciences, University of Liverpool, United Kingdom
contact email	peffs@liverpool.ac.uk
lab head
James Anderson
contact affiliation	University of Liverpool
contact email	janders@liverpool.ac.uk
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD032757

PRIDE project URI

Repository Record List

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