PXD032740

PXD032740 is an original dataset announced via ProteomeXchange.

Title	FAM134B homodimer ubiquitination
Description	FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little is known about the molecular and biophysical mechanisms that control and/or switch between these two FAM134B functions.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:48:56.596.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adriana Covarrubias-Pinto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-23 07:26:53	ID requested
1	2023-06-19 06:48:16	announced
2	2023-11-14 09:01:42	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:48:57	announced	2024-10-22: Updated project metadata.

10.1038/s41586-023-06089-2;

Gonz, á, lez A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Br, ä, uning B, Balakrishnan A, Qualmann B, D, ö, tsch V, Schulman BA, Kessels MM, H, ü, bner CA, Heilemann M, Hummer G, Diki, ć I, Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum. Nature, 618(7964):394-401(2023) [pubmed]

submitter keyword: Venus FAM134B and FAM134C dimers

Ivan Dikic
contact affiliation	Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany
contact email	dikic@biochem2.uni-frankfurt.de
lab head
Adriana Covarrubias-Pinto
contact affiliation	Goethe University
contact email	CovarrubiasPinto@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD032740

PRIDE project URI

• PRIDE
  1. PXD032740
     1. Label: PRIDE project
     2. Name: FAM134B homodimer ubiquitination