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PXD032714

PXD032714 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics and Metabolomics unveils Codonopsis Radix ameliorates Gastric Precancerous Lesions via regulating energy metabolism
DescriptionModern pharmacology has proved that Codonopsis Radix and its active ingredients can treat stomach diseases by ameliorating gastrointestinal motility and regulating oxidase levels. However, the detailed molecular mechanism is still unclear. In this study, we systematically evaluated the pharmacodynamic effects of Codonopsis Radix in Gastric Precancerous Lesions animal models. Considering the combination of proteomics and metabolomics, we found that CR could significantly reversed the biological pathways related to energy metabolism which were disturbed by GPL model. Furthermore, the results of serum pharmacology indicated that the Codonopsis Radix contained serum could ameliorate gastritis injury, and selectively inhibit the proliferation of gastric cancer cells rather than normal cells, which was closely related to ATP production in above cells.
HostingRepositoryPRIDE
AnnounceDate2024-10-07
AnnouncementXMLSubmission_2024-10-07_13:45:45.458.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitter茹芸 马
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList2x(13)C,6x(2)H labeled dimethylated L-arginine; monohydroxylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-23 02:51:59ID requested
12024-10-07 13:45:46announced
Publication List
10.3389/fphar.2022.933096;
He R, Ma R, Jin Z, Zhu Y, Yang F, Hu F, Dai J, Regulating Energy Metabolism. Front Pharmacol, 13():933096(2022) [pubmed]
Keyword List
submitter keyword: proteomics, metabolomics, gastric precancerous lesions, serum pharmacology, energy metabolism,Codonopsis Radix
Contact List
Jianye Dai
contact affiliationSchool of Pharmacy, Lanzhou University, Lanzhou, China
contact emaildaijy@lzu.edu.cn
lab head
茹芸 马
contact affiliationLanZhou University
contact email492587666@qq.com
dataset submitter
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Dataset FTP location
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