PXD032714

PXD032714 is an original dataset announced via ProteomeXchange.

Title	Proteomics and Metabolomics unveils Codonopsis Radix ameliorates Gastric Precancerous Lesions via regulating energy metabolism
Description	Modern pharmacology has proved that Codonopsis Radix and its active ingredients can treat stomach diseases by ameliorating gastrointestinal motility and regulating oxidase levels. However, the detailed molecular mechanism is still unclear. In this study, we systematically evaluated the pharmacodynamic effects of Codonopsis Radix in Gastric Precancerous Lesions animal models. Considering the combination of proteomics and metabolomics, we found that CR could significantly reversed the biological pathways related to energy metabolism which were disturbed by GPL model. Furthermore, the results of serum pharmacology indicated that the Codonopsis Radix contained serum could ameliorate gastritis injury, and selectively inhibit the proliferation of gastric cancer cells rather than normal cells, which was closely related to ATP production in above cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_13:45:45.458.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	茹芸 马
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	2x(13)C,6x(2)H labeled dimethylated L-arginine; monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-23 02:51:59	ID requested
⏵ 1	2024-10-07 13:45:46	announced

10.3389/fphar.2022.933096;

He R, Ma R, Jin Z, Zhu Y, Yang F, Hu F, Dai J, Regulating Energy Metabolism. Front Pharmacol, 13():933096(2022) [pubmed]

submitter keyword: proteomics, metabolomics, gastric precancerous lesions, serum pharmacology, energy metabolism,Codonopsis Radix

Jianye Dai
contact affiliation	School of Pharmacy, Lanzhou University, Lanzhou, China
contact email	daijy@lzu.edu.cn
lab head
茹芸 马
contact affiliation	LanZhou University
contact email	492587666@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032714
     1. Label: PRIDE project
     2. Name: Proteomics and Metabolomics unveils Codonopsis Radix ameliorates Gastric Precancerous Lesions via regulating energy metabolism