PXD032710
PXD032710 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | IgA Nephropathy Proteome Profiling |
| Description | IgA nephropathy (IgAN) is a heterogeneous disease, which poses a series of challenges to accurate diagnosis and personalized therapy. Here, we present a systematic quantitative kidney tissue proteome atlas across 19 tumor-adjacent normal kidney tissues, 12 membranous nephropathy (MN) samples and 59 biopsies from IgAN patients. Consensus sub-clustering of proteome profiles divided IgAN into three subtypes (IgAN-C1, C2 and C3). Compared to IgAN-C2, the IgAN-C1, and C3 subtypes had a different regulating mechanism and exhibited higher levels of complement activation, more severe mitochondrial injury, and more significant extracellular matrix accumulation. Additionally, IgAN-C1 and C3 had worse clinical outcomes than C2 (30% serum creatinine increase as the end point, P<0.01). Overall, the novel proteomic prognostic subtyping of IgAN could help us understand the heterogeneity of IgAN and improve clinical outcomes. |
| HostingRepository | iProX |
| AnnounceDate | 2022-03-22 |
| AnnouncementXML | Submission_2023-03-29_00:31:22.621.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yang Lu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Thermo Finnigan instrument model; Orbitrap Fusion; Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-03-22 19:48:34 | ID requested | |
| 1 | 2022-03-22 19:49:01 | announced | |
| ⏵ 2 | 2023-03-29 00:31:23 | announced | 2023-03-29: Update publication information. |
Publication List
| Chen X, Li M, Zhu S, Lu Y, Duan S, Wang X, Wang Y, Chen P, Wu J, Wu D, Feng Z, Cai G, Zhu Y, Deng H, Chen X, Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes. iScience, 26(3):105961(2023) [pubmed] |
Keyword List
| submitter keyword: IgA Nephropathy, Proteomics, Classification |
Contact List
| Xiangmei Chen | |
|---|---|
| contact affiliation | First Medical Center of Chinese PLA General Hospital |
| contact email | xmchen301@126.com |
| lab head | |
| Yang Lu | |
| contact affiliation | First Medical Center of Chinese PLA General Hospital |
| contact email | lvyang1978@hotmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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